Endoplasmic Reticulum Stress Compound Library

Catalog No. L9700

Library Compound List Excel SDF

The endoplasmic reticulum (ER) is the cellular organelle that is critical for protein folding and secretion, calcium homeostasis, and lipid biosynthesis. The ER is the site of multiple post-translational modifications such as glycosylation and disulfide bond formation. It is also the organelle in which proteins are folded into their proper conformation and in which multi-subunit proteins are assembled. Endoplasmic reticulum stress (ER stress), such as unfolded protein response (UPR) and ER overload response (EOR), occurs when proteins are not properly folded or conformed (misfolded protein) or homeostasis cannot be maintained such as disturbances in redox regulation, calcium regulation, glucose deprivation, and viral infection. As a result, ER-localized chaperones such as glucose-regulated proteins (GRP78, GRP94, etc.) are induced, protein synthesis is slowed down, and a protein degrading system is initiated. However, excessive and prolonged stresses lead cells to caspase-12 mediated apoptosis.

ER stress occurs not only in both normal and pathophysiological conditions, but has also been implicated in multiple disorders such as cancers, type 2 diabetes, ischemia, viral infection, and neurodegenerative disorders. ER stress can also be induced by hypoxia. This has implications for solid tumors which usually exhibit hypoxia in their cores. Insulin resistance is also associated with ER stress and the treatment of type 2 diabetic mice with chemical chaperones which assist protein folding in the ER restored insulin sensitivity. It has also been proposed that agents that cause ER stress can be used directly as chemotherapeutic agents.

TargetMol’s Endoplasmic Reticulum Stress Compound Library collects 193 ER stress related compounds, targeting different targets in ER stress signaling pathway such as PERK, IRE1, ATF6, GRP78, etc. It is an effective tool for research in endoplasmic reticulum stress and related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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Product Description

A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
Targets include GRP78, IRE1, ATF6, PERK, etc.
Some compounds have been approved by FDA;
Structurally diverse, medicinally active, and cell permeable;
Rich documentation with chemical structure, target, and bioactivity information;
NMR and HPLC validated to ensure high purity.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Apoptosis (63)

Autophagy (51)

HSP (34)

PERK (18)

JNK (15)

IRE1 (15)

Endogenous Metabolite (13)

Mitophagy (9)

AMPK (8)

NF-κB (7)

Antibiotic (7)

COX (7)

Antibacterial (7)

GPR (6)

Reactive Oxygen Species (6)

P450 (6)

p97 (5)

ERK (5)

HIV Protease (5)

Akt (4)

Phosphatase (4)

PPAR (4)

MEK (4)

DNA/RNA Synthesis (3)

Caspase (3)

Calcium Channel (3)

Prostaglandin Receptor (3)

MMP (3)

GABA Receptor (3)

HDAC (3)

Ferroptosis (3)

c-Kit (3)

5-HT Receptor (3)

Mitochondrial Metabolism (3)

FLT (2)

PDGFR (2)

Mdm2 (2)

Aurora Kinase (2)

Lipoxygenase (2)

Sodium Channel (2)

DUB (2)

SARS-CoV (2)

mTOR (2)

HIF (2)

TGF-beta/Smad (2)

Phospholipase (2)

MAPK (2)

AChE (2)

Casein Kinase (2)

ASK (2)

Sirtuin (2)

Proteasome (2)

CDK (2)

Chloride channel (2)

Estrogen/progestogen Receptor (2)

Antifungal (2)

VEGFR (2)

Antioxidant (2)

PI3K (2)

Glutathione Peroxidase (2)

Gamma-secretase (2)

Histamine Receptor (2)

Src (2)

NADPH (1)

PDK (1)

Histone Demethylase (1)

Dehydrogenase (1)

p38 MAPK (1)

Integrin (1)

HCV Protease (1)

Adenosine deaminase (1)

TNF (1)

Dopamine Receptor (1)

Microtubule Associated (1)

Kinesin (1)

p53 (1)

NOD-like Receptor (NLR) (1)

HIF/HIF Prolyl-Hydroxylase (1)

ATPase (1)

Tyrosinase (1)

HMG-CoA Reductase (1)

Beta Amyloid (1)

Transferase (1)

Monocarboxylate transporter (1)

ROR (1)

AChR (1)

Cannabinoid Receptor (1)

Potassium Channel (1)

GPX (1)

CETP (1)

IκB/IKK (1)

Androgen Receptor (1)

Hexokinase (1)

PROTAC Linker (1)

MTH1 (1)

Stearoyl-CoA Desaturase (SCD) (1)

HSV (1)

PTEN (1)

PDE (1)

UGT (1)

E1/E2/E3 Enzyme (1)

Epigenetic Reader Domain (1)

CaMK (1)

Topoisomerase (1)

Glucocorticoid Receptor (1)

RANKL/RANK (1)

TRP/TRPV Channel (1)

Influenza Virus (1)

Tyrosine Kinases (1)

Raf (1)

Nrf2 (1)

Trk receptor (1)

Melatonin Receptor (1)

MRP (1)

HBV (1)

P-gp (1)

Interleukin (1)

Parasite (1)

Cysteine Protease (1)

PGE Synthase (1)

Nucleoside Antimetabolite/Analog (1)

FXR (1)

ATP Citrate Lyase (1)

HER (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty