Home Tools
Log in
Cart

Endoplasmic Reticulum Stress Compound Library

Catalog No. L9700
  Library Compound List   Excel SDF

The endoplasmic reticulum (ER) is the cellular organelle that is critical for protein folding and secretion, calcium homeostasis, and lipid biosynthesis. The ER is the site of multiple post-translational modifications such as glycosylation and disulfide bond formation. It is also the organelle in which proteins are folded into their proper conformation and in which multi-subunit proteins are assembled. Endoplasmic reticulum stress (ER stress), such as unfolded protein response (UPR) and ER overload response (EOR), occurs when proteins are not properly folded or conformed (misfolded protein) or homeostasis cannot be maintained such as disturbances in redox regulation, calcium regulation, glucose deprivation, and viral infection. As a result, ER-localized chaperones such as glucose-regulated proteins (GRP78, GRP94, etc.) are induced, protein synthesis is slowed down, and a protein degrading system is initiated. However, excessive and prolonged stresses lead cells to caspase-12 mediated apoptosis.

ER stress occurs not only in both normal and pathophysiological conditions, but has also been implicated in multiple disorders such as cancers, type 2 diabetes, ischemia, viral infection, and neurodegenerative disorders. ER stress can also be induced by hypoxia. This has implications for solid tumors which usually exhibit hypoxia in their cores. Insulin resistance is also associated with ER stress and the treatment of type 2 diabetic mice with chemical chaperones which assist protein folding in the ER restored insulin sensitivity. It has also been proposed that agents that cause ER stress can be used directly as chemotherapeutic agents.

TargetMol’s Endoplasmic Reticulum Stress Compound Library collects 193 ER stress related compounds, targeting different targets in ER stress signaling pathway such as PERK, IRE1, ATF6, GRP78, etc. It is an effective tool for research in endoplasmic reticulum stress and related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Please contact us for prices and availability for the specification of product you are interested at.
Get quote
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
Get quote

Product Features

  • A unique collection of 155 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
  • Targets include GRP78, IRE1, ATF6, PERK, etc.
  • Some compounds have been approved by FDA;
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with chemical structure, target, and bioactivity information;
  • NMR and HPLC validated to ensure high purity.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L9700)

Library Composition

HSP (31)
JNK (13)
PERK (11)
IRE1 (7)
ERK (6)
Apoptosis (6)
NF-κB (6)
GPR (5)
Autophagy (5)
p97 (5)
P450 (5)
AMPK (5)
COX (5)
Endogenous Metabolite (4)
Estrogen/progestogen Receptor (4)
MEK (4)
Prostaglandin Receptor (3)
c-Kit (3)
HDAC (3)
Akt (3)
HMG-CoA Reductase (3)
Src (2)
PPAR (2)
Mitochondrial Metabolism (2)
MMP (2)
Sirtuin (2)
AChR (2)
Histamine Receptor (2)
PDGFR (2)
Proteasome (2)
Phospholipase (2)
GABA Receptor (2)
Mdm2 (2)
5-HT Receptor (2)
FLT (2)
CDK (2)
Antibiotic (2)
Antioxidant (2)
ASK (2)
ATPase (2)
Aurora Kinase (2)
Calcium Channel (2)
Casein Kinase (2)
Caspase (2)
VEGFR (2)
DUB (2)
E1/E2/E3 Enzyme (1)
p53 (1)
Beta Amyloid (1)
PDE (1)
HBV (1)
GPX (1)
P-gp (1)
Phosphatase (1)
ATP Citrate Lyase (1)
PI3K (1)
Potassium Channel (1)
Dopamine Receptor (1)
p38 MAPK (1)
GHSR (1)
ROR (1)
Antibacterial (1)
Sodium Channel (1)
Androgen Receptor (1)
Trk receptor (1)
TRP/TRPV Channel (1)
Tyrosinase (1)
Tyrosine Kinases (1)
UGT (1)
Glucocorticoid Receptor (1)
CaMK (1)
Histone Demethylase (1)
HIF (1)
HIV Protease (1)
DNA/RNA Synthesis (1)
Dehydrogenase (1)
Integrin (1)
Cysteine Protease (1)
IκB/IKK (1)
Chloride channel (1)
Lipoxygenase (1)
MAPK (1)
CETP (1)
Melatonin Receptor (1)
Nucleoside Antimetabolite/Analog (1)
Microtubule Associated (1)
Hexokinase (1)
HER (1)
Monocarboxylate transporter (1)
MPO (1)
MRP (1)
Epigenetic Reader Domain (1)
mTOR (1)
NADPH (1)
Cannabinoid Receptor (1)
NOD-like Receptor (NLR) (1)
MTH1 (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE