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Ferroptosis Compound Library

Catalog No. L8700
  Library Compound List   Excel SDF

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically, biochemically and morphologically distinct from other forms of regulated cell death such as apoptosis, necroptosis, and autophagic cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. Understanding the molecular mechanisms and signaling pathways of ferroptosis may provide new diagnostic and therapeutic approaches to regulate cell survival and death in human disease.

TargetMol collects 800 compounds related to ferroptosis signaling pathway with targets including GPX4, System Xc−, HSPB1, NRF2, VDAC2/3, Ras, TFR1, NOX, p53, CARS, ROS, SLC7A11, etc. Iron chelators and lipid peroxidation inhibitors are also included in this library.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study;
  • Covers various targets such as GPX4, ROS, p53, Nrf2, etc.;
  • Some compounds are FDA approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L8700)

Library Composition

Antioxidant (88)
ROS (39)
NF-κB (32)
p53 (24)
COX (22)
Endogenous Metabolite (20)
Raf (19)
Autophagy (16)
Nrf2 (15)
PPAR (15)
P450 (15)
TNF (15)
Apoptosis (14)
Mdm2 (13)
Calcium Channel (11)
Ferroptosis (11)
DPP-4 (11)
MEK (11)
Dehydrogenase (11)
Lipoxygenase (11)
STAT (10)
Antibacterial (10)
DNA/RNA Synthesis (9)
AChR (9)
MMP (9)
ERK (9)
HMG-CoA Reductase (9)
Estrogen/progestogen Receptor (8)
5-HT Receptor (8)
p38 MAPK (8)
Antibiotic (8)
Vitamin (8)
IL Receptor (7)
Tyrosinase (7)
HIF (7)
PKC (7)
Histamine Receptor (7)
Dopamine Receptor (7)
VEGFR (6)
Akt (6)
EGFR (6)
AMPK (6)
Glucokinase (6)
Sirtuin (6)
Ras (6)
BCL (6)
CDK (6)
IκB/IKK (5)
Rho (5)
MAO (5)
NADPH (5)
NOS (5)
PDGFR (4)
Src (4)
Trk receptor (4)
HIV Protease (4)
RAAS (4)
PI3K (4)
GABA Receptor (4)
JNK (4)
ATPase (4)
Caspase (4)
Adrenergic Receptor (4)
Beta Amyloid (4)
BACE (4)
Free radical scavengers (3)
Parasite (3)
PARP (3)
Aurora Kinase (3)
Potassium Channel (3)
Reductase (3)
MAPK (3)
Reverse Transcriptase (3)
Antifection (3)
TGF-beta/Smad (3)
ALK (3)
AhR (3)
Wnt/beta-catenin (3)
NADPH-oxidase (3)
Carbonic Anhydrase (3)
GPX (3)
Epigenetic Reader Domain (3)
Phospholipase (2)
cell cycle arrest (2)
NMDAR (2)
NOD (2)
SGLT (2)
Serine Protease (2)
Opioid Receptor (2)
S6 Kinase (2)
Antifungal (2)
CaMK (2)
ribosome (2)
Antiviral (2)
mTOR (2)
PDE (2)
HSP (2)
HDAC (2)
PKA (2)
GSK-3 (2)
PKM (2)
GTPase (2)
Aromatase (2)
Prostaglandin Receptor (2)
Sodium Channel (2)
Proteasome (2)
Mitochondrial Metabolism (2)
FGFR (2)
Glucocorticoid Receptor (2)
Cysteine Protease (2)
Amino Acids and Derivatives (2)
TLR (2)
UGT (2)
Influenza Virus (2)
TRP/TRPV Channel (2)
DNA Alkylation (2)
c-Kit (2)
GluR (2)
FLT (2)
HSV (2)
Gamma-secretase (1)
Reactive Oxygen Species (1)
Retinoid Receptor (1)
Wnk (1)
Tyrosine Kinases (1)
advanced glycation end products (1)
ROR (1)
transporter (1)
stilbene oxidase (1)
Transferase (1)
Topoisomerase (1)
SARS-CoV (1)
Thyroid hormone receptor(THR) (1)
Sigma receptor (1)
Thioredoxin (1)
Glutathione reductase (1)
Telomerase (1)
ASK (1)
Syk (1)
Annexin A (1)
Androgen Receptor (1)
Somatostatin (1)
DNA gyrase (1)
ATM/ATR (1)
Lipid (1)
Chloride channel (1)
DUB (1)
c-Met/HGFR (1)
lysosomal autophagy (1)
LRRK2 (1)
Liver X Receptor (1)
c-RET (1)
LDL (1)
Microtubule Associated (1)
Keap1-Nrf (1)
CXCR (1)
IRAK (1)
Integrin (1)
Immunology & Inflammation related (1)
IAP (1)
Hydroxylase (1)
Hydrogenase (1)
Melatonin Receptor (1)
Mitophagy (1)
Proton pump (1)
P2X Receptor (1)
GST (1)
PLK (1)
HCV Protease (1)
P-gp (1)
Hedgehog/Smoothened (1)
Hexokinase (1)
BMI-1 (1)
cAMP (1)
FXR (1)
CFTR (1)
Casein Kinase (1)
NPC1L1 (1)
HIF/HIF Prolyl-Hydroxylase (1)
NOD-like Receptor (NLR) (1)
NO Synthase (1)
E1/E2/E3 Enzyme (1)
c-Fms (1)
MPO (1)
Xanthine Oxidase (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE