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Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
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MAPK Inhibitor Library

Catalog No. L1400
  Library Compound List   Excel SDF

Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs.

The MAPK Inhibitor Library by TargetMol, containing 367 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
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Product Description

  • A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L1400)

Publications Cited TargetMol Libraries

1. Acta Pharmaceutica Sinica B. 2020. 2. Toxicology and Applied Pharmacology. 2023: 116792. 3. Cell Stem Cell. 2022 Apr 29(4) 545–558. 4. Science Bulletin. 2022. 5. Science Translational Medicine. 2022, 14(656): eabn3231. 6. Science Advances. 2023, 9(9): eade3760. 7. Nature. 2020, 582: 289-293. 8. Nature Biotechnology. 2021, 39(11): 1444-1452. 9. Nature Communications. 2022, 13(1): 1-15..
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Library Composition

ERK (64)
p38 MAPK (55)
Raf (54)
MEK (36)
JNK (32)
MAPK (24)
Ras (24)
S6 Kinase (20)
CDK (20)
NF-κB (18)
Akt (15)
Src (12)
VEGFR (11)
Rho (9)
Aurora Kinase (9)
PDGFR (7)
c-Kit (7)
PKA (6)
TGF-beta/Smad (6)
c-RET (6)
MLK (6)
Apoptosis (6)
Bcr-Abl (5)
Caspase (5)
FLT (5)
PI3K (5)
MNK (4)
GSK-3 (4)
PKC (4)
mTOR (4)
ASK (4)
DNA/RNA Synthesis (4)
STAT (4)
COX (4)
Casein Kinase (4)
TNF (4)
Serine Protease (3)
EGFR (3)
Endogenous Metabolite (3)
TOPK (3)
Autophagy (3)
FGFR (3)
P450 (3)
Trk receptor (3)
Antiviral (3)
LRRK2 (3)
Tyrosine Kinases (2)
BCL (2)
SGK (2)
ROCK (2)
PERK (2)
GTPase (2)
DNA Alkylation (2)
ROS (2)
Proton pump (2)
c-Met/HGFR (2)
IGF-1R (2)
Tie-2 (1)
PARP (1)
PAI-1 (1)
PAFR (1)
Transferase (1)
Syk (1)
Tyrosinase (1)
Sodium Channel (1)
Potassium Channel (1)
5-HT Receptor (1)
Nrf2 (1)
Antifungal (1)
Calcium Channel (1)
BMI-1 (1)
Beta Amyloid (1)
BACE (1)
Aromatase (1)
Antioxidant (1)
Antifection (1)
Chk (1)
Antibacterial (1)
AMPK (1)
ALK (1)
AhR (1)
Adrenergic Receptor (1)
ACK (1)
c-Fms (1)
c-Myc (1)
NO Synthase (1)
AChR (1)
NADPH-oxidase (1)
MMP (1)
JAK (1)
IκB/IKK (1)
Integrin (1)
IL Receptor (1)
Histamine Receptor (1)
CSF-1R (1)
GPX (1)
Glucokinase (1)
FAK (1)
Estrogen/progestogen Receptor (1)
Ephrin Receptor (1)
DNA (1)
Hydroxylase (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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