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Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
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Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
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Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

RO5 Drug-like Natural Product Library

Catalog No. L6160
  Library Compound List   Excel SDF

Natural products are important sources of lead compounds and drug candidates. They have complex scaffold structures and rich functional groups. Their structures are unique, and most of them are chiral. These naturally occurring advantages provide more diverse options for the transformation of natural products into drugs, and are also the reasons why natural products play an important role in drug development and research.

Based on the structural diversity and novelty of natural products, TargetMol used the druglikeness prediction index "Lipinski's Rule of Five" to select 2743 natural product monomers with good druggabilities, covering diverse structures from vast sources such as terpenes and alkaloids. The library is consisted of monomers with both biological activity and drug-like properties. It is a powerful tool for subsequent structure-effect optimization and innovative drug research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • 2743 is a collection of natural products that meet the "Lipinski's Rule of Five" and have high potential for drug discovery.
  • Most of the NPs have clear biological activities, with various functions including anti-tumor, anti-inflammatory, antioxidant, neuroprotection and more.
  • Structural diversity, containing flavonoids, saponins, terpenoids, alkaloids and other categories.
  • Various detection techniques such as NMR, HPLC/LCMS to ensure accurate structure and high purity of the products and reduce false positives.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L6160)

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..
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Library Composition

Endogenous Metabolite (803)
Apoptosis (258)
Antibacterial (218)
Autophagy (170)
NF-κB (112)
Antifungal (102)
Antibiotic (85)
Reactive Oxygen Species (74)
Parasite (66)
COX (61)
Antioxidant (61)
AChR (53)
P450 (52)
Influenza Virus (44)
Anti-infection (43)
DNA/RNA Synthesis (42)
TNF (38)
AChE (38)
GABA Receptor (35)
p38 MAPK (35)
IL Receptor (32)
5-HT Receptor (32)
Calcium Channel (31)
Caspase (31)
Tyrosinase (31)
ERK (31)
Ferroptosis (29)
STAT (29)
HIV Protease (29)
Akt (29)
NO Synthase (28)
Estrogen/progestogen Receptor (27)
Topoisomerase (26)
Adrenergic Receptor (26)
Nrf2 (24)
Virus Protease (24)
AMPK (24)
TRP/TRPV Channel (22)
PI3K (21)
PPAR (21)
MMP (21)
ROS (21)
Lipoxygenase (20)
Dopamine Receptor (20)
Estrogen Receptor/ERR (20)
BCL (19)
NOS (19)
Potassium Channel (18)
Antifection (18)
PDE (18)
PKC (17)
Dehydrogenase (16)
HSV (16)
Microtubule Associated (16)
PARP (16)
JNK (16)
Nucleoside Antimetabolite/Analog (15)
EGFR (15)
Mitophagy (14)
iGluR (14)
Adenosine Receptor (13)
Glucosidase (13)
HDAC (13)
Histamine Receptor (13)
Prostaglandin Receptor (13)
Drug Metabolite (13)
Mitochondrial Metabolism (12)
Sodium Channel (12)
HIF/HIF Prolyl-Hydroxylase (12)
Amino Acids and Derivatives (12)
Antiviral (12)
VEGFR (12)
Androgen Receptor (11)
MAO (11)
P-gp (11)
Wnt/beta-catenin (11)
GluR (11)
ATPase (10)
Immunology/Inflammation related (10)
JAK (10)
NMDAR (10)
Glucocorticoid Receptor (10)
HBV (9)
CDK (9)
SARS-CoV (9)
Monoamine Oxidase (9)
Sirtuin (9)
Opioid Receptor (8)
TLR (7)
HCV Protease (7)
TGF-beta/Smad (7)
Phospholipase (7)
Progesterone Receptor (7)
NOD (7)
Indoleamine 2,3-Dioxygenase (IDO) (6)
HER (6)
HIF (6)
HMG-CoA Reductase (6)
Interleukin (6)
Beta Amyloid (6)
GPR (6)
Cannabinoid Receptor (6)
Chloride channel (6)
IκB/IKK (6)
MAPK (6)
Fatty Acid Synthase (6)
mTOR (6)
PKA (6)
Phosphatase (5)
Src (5)
Reductase (5)
Platelet aggregation (5)
AhR (5)
PAFR (5)
Reverse Transcriptase (5)
NADPH (5)
Xanthine Oxidase (5)
HSP (5)
transporter (5)
Carbonic Anhydrase (5)
FXR (5)
Gamma-secretase (5)
Transferase (5)
Aryl Hydrocarbon Receptor (5)
BACE (5)
LDL (4)
ribosome (4)
MEK (4)
CaMK (4)
FGFR (4)
ATP Citrate Lyase (4)
p53 (4)
c-Met/HGFR (4)
cAMP (4)
DNA Methyltransferase (4)
Serine/threonin kinase (4)
Arginase (4)
PGE Synthase (4)
UGT (4)
Syk (4)
CCR (3)
Trk receptor (3)
Serotonin Transporter (3)
IAP (3)
MRP (3)
DNA (3)
Beta-Secretase (3)
DHFR (3)
Tyrosine Kinases (3)
ROR (3)
Epigenetic Reader Domain (3)
GSK-3 (3)
Telomerase (3)
Proton pump (3)
Imidazoline Receptor (3)
Thyroid hormone receptor(THR) (3)
Hedgehog/Smoothened (3)
Integrin (3)
GST (3)
Aromatase (3)
Glutathione Peroxidase (3)
GPCR19 (3)
Lipid (3)
Free radical scavengers (3)
FAK (3)
PDK (2)
PDGFR (2)
PKM (2)
ATM/ATR (2)
Casein Kinase (2)
Ras (2)
PAK (2)
PAI-1 (2)
Proteasome (2)
Phosphorylase (2)
Aurora Kinase (2)
Thrombin (2)
c-Myc (2)
Serine Protease (2)
IGF-1R (2)
RAAS (2)
Histone Acetyltransferase (2)
gp120/CD4 (2)
LTR (2)
Smo (2)
FAAH (2)
E1/E2/E3 Enzyme (2)
Aminopeptidase (2)
DPP-4 (2)
DYRK (2)
DNA gyrase (2)
Decarboxylase (2)
CXCR (2)
OAT (2)
DNA Alkylator/Crosslinker (2)
Cysteine Protease (2)
S6 Kinase (2)
NOD-like Receptor (NLR) (2)
RANKL/RANK (2)
S1P Receptor (1)
Transaminase (1)
Acyltransferase (1)
Somatostatin (1)
aconitase (1)
Stearoyl-CoA Desaturase (SCD) (1)
RAR/RXR  (1)
ROS Kinase (1)
SGLT (1)
Retinoid Receptor (1)
Antifolate (1)
Raf (1)
Factor Xa (1)
ABC (1)
IDO (1)
Hydroxylase (1)
Hydrogenase (1)
Hexokinase (1)
hCE (1)
GlyT (1)
FLT (1)
ALK (1)
IRE1 (1)
DNA Alkylation (1)
CYP19A1 (1)
CRISPR/Cas9 (1)
CFTR (1)
CD38 (1)
CAT (1)
Carboxypeptidase (1)
BCRP (1)
ATTECs (1)
IRAK (1)
Leukotriene Receptor (1)
Pyroptosis (1)
OCT (1)
Prolyl Endopeptidase (PREP) (1)
PLK (1)
Pim (1)
PD-1/PD-L1 (1)
PAD (1)
Adenylyl cyclase (1)
Adiponectin receptor (1)
P2Y Receptor (1)
P2X Receptor (1)
Norepinephrine (1)
LPL Receptor (1)
NMU2R (1)
advanced glycation end products (1)
Neurokinin receptor (1)
NADPH-oxidase (1)
MT Receptor (1)
Monocarboxylate transporter (1)
Monoamine Transporter (1)
Melatonin Receptor (1)
Mdm2 (1)
Liver X Receptor (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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