Target-Focused Phenotypic Screening Library

Catalog No. L9500

Library Compound List Excel SDF

TargetMol offers a high quality Target-focused Phenotypic Screening Library (2142 compounds in total) with maximal biological and chemical diversity for such empirical approaches. Phenotypic approaches use semi-empirical methods that do not require much knowledge of the target and understanding of the mechanism. A recent analysis revealed the phenotypic approaches to be the more successful strategy for small-molecule, first-in-class medicines. The rationalization for this success was the unbiased identification of the molecular mechanism of action (MMOA). In addition, an understanding of mechanism is not required for regulatory approval; the regulatory agencies are less concerned with the MMOA of a compound than with whether it is effective. It can be argued that in seeking the best path to new medicines, academic science should be focusing not on gene-based, hypothesis-driven research but on translating disease knowledge into disease-relevant phenotypic assays for screening and chemical biology approaches to screening and target identification as well as on systematic approaches to understanding the MMOA. Greater focus on translational research should lead to greater access to more reliable phenotypic assays.

Use of well-annotated bioactive compounds with clear targets for phenotypic screening can also narrow the scope of targets that are needed to be validated, therefore, it is an effective tool for target identification or validation.

Given the potential applications of a Phenotypic Screening Library, the focus of the compounds selection strategy lies on biodiversity and maximal coverage of chemical space, aimed at providing hits for a wide spectrum of biological goals. This library finally was developed to contain a set of compounds with confirmed biological activity for more than 600 drug targets and includes 2-4 structurally diverse compounds for each target.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 2142 annotated bioactive compounds with clear targets, suitable for phenotypic screening；
Cover more than 600 drug targets, Structurally diverse；
2-4 structurally diversified compounds for the same annotated 'on-target' to increase the success rate of target identification (enables the generation of much stronger target–phenotype hypotheses);
Detailed information about compound structure, target, activity, etc.；
NMR and HPLC/LCMS validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Library Composition

Apoptosis (272)

Autophagy (260)

Endogenous Metabolite (93)

Antibacterial (91)

5-HT Receptor (71)

Antibiotic (59)

AChR (53)

DNA/RNA Synthesis (52)

Adrenergic Receptor (50)

P450 (45)

VEGFR (45)

Dopamine Receptor (44)

HIV Protease (40)

PI3K (36)

Epigenetic Reader Domain (36)

PDE (34)

COX (32)

FGFR (32)

PDGFR (31)

Influenza Virus (31)

Histamine Receptor (31)

CDK (30)

Ferroptosis (30)

Parasite (29)

FLT (28)

NF-κB (28)

Potassium Channel (27)

c-Kit (27)

TRP/TRPV Channel (27)

Src (27)

PPAR (24)

Histone Methyltransferase (24)

HCV Protease (24)

GluR (24)

Raf (24)

Reactive Oxygen Species (23)

EGFR (23)

Calcium Channel (23)

Dehydrogenase (23)

TGF-beta/Smad (22)

Mitophagy (22)

Microtubule Associated (22)

JAK (21)

SARS-CoV (20)

HDAC (20)

Topoisomerase (20)

BCL (20)

Estrogen/progestogen Receptor (19)

mTOR (19)

Adenosine Receptor (19)

GABA Receptor (19)

GPR (18)

Sodium Channel (18)

Beta Amyloid (18)

Bcr-Abl (18)

c-Met/HGFR (18)

MAO (17)

p38 MAPK (17)

PKC (17)

Antifungal (17)

IL Receptor (16)

Wnt/beta-catenin (16)

ALK (16)

RAAS (16)

Opioid Receptor (16)

Proteasome (16)

Retinoid Receptor (16)

Estrogen Receptor/ERR (15)

TNF (15)

Carbonic Anhydrase (15)

E1/E2/E3 Enzyme (15)

IκB/IKK (15)

MMP (15)

Prostaglandin Receptor (14)

STAT (14)

GSK-3 (14)

Monoamine Oxidase (14)

DNA Alkylator/Crosslinker (14)

Virus Protease (14)

Akt (14)

Gamma-secretase (13)

ROR (13)

ATPase (13)

ERK (13)

Sirtuin (13)

NMDAR (12)

Phosphatase (12)

Aurora Kinase (12)

c-RET (12)

P2 Receptor (12)

CXCR (12)

HSV (12)

NADPH (12)

HSP (12)

DNA Alkylation (12)

Interleukin (12)

Trk receptor (11)

S1P Receptor (11)

PKA (11)

iGluR (11)

Glucokinase (11)

HIF/HIF Prolyl-Hydroxylase (11)

Serine Protease (11)

Lipoxygenase (11)

MEK (11)

ribosome (11)

Caspase (11)

Nucleoside Antimetabolite/Analog (11)

DUB (10)

DNA Methyltransferase (10)

Chk (10)

Casein Kinase (10)

JNK (10)

Glucocorticoid Receptor (10)

PARP (10)

Indoleamine 2,3-Dioxygenase (IDO) (10)

ROCK (10)

Hedgehog/Smoothened (10)

Phospholipase (9)

AMPK (9)

P-gp (9)

LPL Receptor (9)

Norepinephrine (9)

Reverse Transcriptase (9)

SGLT (9)

ATM/ATR (9)

Serine/threonin kinase (9)

Cannabinoid Receptor (9)

Serotonin Transporter (9)

CaMK (9)

CFTR (8)

AChE (8)

PLK (8)

p53 (8)

Syk (8)

Cysteine Protease (8)

DNA-PK (8)

Drug Metabolite (8)

Ras (8)

Endothelin Receptor (8)

TLR (8)

c-Fms (8)

S6 Kinase (8)

Transferase (8)

HIF (8)

HBV (8)

HER (8)

Aryl Hydrocarbon Receptor (7)

Monocarboxylate transporter (7)

Proton pump (7)

CCR (7)

Reductase (7)

Thyroid hormone receptor(THR) (7)

TAM Receptor (7)

HMG-CoA Reductase (7)

NOS (7)

Tyrosine Kinases (6)

AhR (6)

NOD (6)

Mdm2 (6)

Mitochondrial Metabolism (6)

Histone Acetyltransferase (6)

ROS (6)

OX Receptor (6)

FAK (6)

Rho (6)

Acyltransferase (6)

Chloride channel (6)

Smo (6)

Sigma receptor (6)

Lipase (6)

PDK (6)

PKM (6)

BTK (6)

Aromatase (6)

PAK (5)

PD-1/PD-L1 (5)

DNA gyrase (5)

DNA (5)

PERK (5)

DPP-4 (5)

NAMPT (5)

DHFR (5)

Telomerase (5)

Histone Demethylase (5)

Phosphorylase (5)

IDO (5)

Androgen Receptor (5)

MAPK (5)

MRP (5)

Factor Xa (5)

LRRK2 (5)

FAAH (5)

Kinesin (5)

FXR (5)

ATP Citrate Lyase (5)

IGF-1R (5)

Glutathione Peroxidase (5)

BACE (4)

Acetyl-CoA Carboxylase (4)

GPCR19 (4)

RIP kinase (4)

PAI-1 (4)

transporter (4)

ABC (4)

BMI-1 (4)

PGE Synthase (4)

Tie-2 (4)

Lipid (4)

Xanthine Oxidase (4)

IRE1 (4)

p97 (4)

Porcupine (4)

CAT (4)

NO Synthase (4)

Monoamine Transporter (4)

Ephrin Receptor (4)

Annexin A (4)

Progesterone Receptor (4)

Fatty Acid Synthase (4)

Tyrosinase (4)

Melatonin Receptor (4)

NOD-like Receptor (NLR) (4)

cAMP (4)

CaSR (4)

LTR (4)

CSF-1R (4)

MNK (4)

UGT (3)

Survivin (3)

RSV (3)

PTEN (3)

STING (3)

IRAK (3)

Pim (3)

Na+/Ca2+ Exchanger (3)

ACK (3)

advanced glycation end products (3)

Cell wall (3)

CETP (3)

c-Myc (3)

DprE1 (3)

Free radical scavengers (3)

Hydroxylase (3)

Leukotriene Receptor (3)

LIM Kinase (3)

Liver X Receptor (3)

GNRH Receptor (3)

Neurokinin receptor (3)

P2X Receptor (3)

Neprilysin (3)

Pyroptosis (2)

Carboxypeptidase(CPG2) (2)

Gap Junction Protein (2)

DYRK (2)

Myosin (2)

CRISPR/Cas9 (2)

Thrombin (2)

BCRP (2)

Beta-Secretase (2)

GlyT (2)

Antiviral (2)

Antioxidant (2)

Antifolate (2)

Antifection (2)

Vasopressin Receptor (2)

Wee1 (2)

PAFR (2)

GluCls (2)

Stearoyl-CoA Desaturase (SCD) (2)

PI4K (2)

Protease-activated Receptor (2)

MTH1 (2)

MT Receptor (2)

MLK (2)

LPA Receptor (2)

NADPH-oxidase (2)

LDL (2)

Integrin (2)

IFNAR (2)

YAP (2)

GRK (2)

OCT (1)

lysosomal autophagy (1)

SGK (1)

Adenosine deaminase (1)

GPX (1)

Adenylyl cyclase (1)

PAD (1)

VDA (1)

Amino Acids and Derivatives (1)

Aminopeptidase (1)

GST (1)

Nrf2 (1)

Anti-infection (1)

Hck (1)

Na-K-Cl cotransporter (1)

Arginase (1)

Glutathione reductase (1)

Neuropeptide Y Receptor (1)

Discoidin Domain Receptor (DDR) (1)

Hippo pathway (1)

IAP (1)

ASK (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty