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Tyrosine Kinase Inhibitor Library

Catalog No. L2200
  Library Compound List   Excel SDF

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis.

The Tyrosine Kinase Inhibitors Library by TargetMol, containing 746 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 746 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2200)

Library Composition

EGFR (136)
VEGFR (126)
Apoptosis (125)
Autophagy (97)
FLT (78)
PDGFR (77)
Src (75)
FGFR (69)
c-Kit (61)
c-Met/HGFR (60)
JAK (51)
Bcr-Abl (49)
ALK (45)
Tyrosine Kinases (35)
HER (34)
PKA (33)
BTK (32)
TAM Receptor (31)
Trk receptor (30)
c-RET (30)
Raf (28)
IGF-1R (24)
CDK (24)
FAK (23)
MEK (22)
TGF-beta/Smad (21)
Syk (20)
Aurora Kinase (20)
c-Fms (20)
PKC (16)
PI3K (13)
ERK (13)
Endogenous Metabolite (12)
Potassium Channel (11)
NF-κB (11)
mTOR (11)
Akt (11)
CSF-1R (11)
Ephrin Receptor (10)
Antibacterial (9)
DYRK (9)
ROS (8)
5-HT Receptor (8)
p38 MAPK (8)
Discoidin Domain Receptor (DDR) (7)
S6 Kinase (7)
Tyrosinase (7)
Tie-2 (6)
Mitophagy (6)
ROCK (6)
Influenza Virus (6)
Ferroptosis (6)
DNA-PK (6)
Antibiotic (5)
ATM/ATR (5)
GSK-3 (5)
Casein Kinase (5)
Chk (5)
Reactive Oxygen Species (4)
MLK (4)
Microtubule Associated (4)
HSP (4)
PYK2 (4)
PPAR (4)
IκB/IKK (4)
JNK (4)
Parasite (4)
Antifungal (4)
Drug Metabolite (4)
ACK (4)
TNF (4)
CaMK (4)
SARS-CoV (4)
PDE (4)
Serine/threonin kinase (4)
STAT (4)
DNA/RNA Synthesis (4)
Adrenergic Receptor (3)
PLK (3)
Caspase (3)
COX (3)
Dehydrogenase (3)
MAPK (3)
Hck (3)
Sodium Channel (3)
SGK (3)
HDAC (3)
Histamine Receptor (3)
AChR (3)
P450 (3)
HIV Protease (3)
Adenosine Receptor (3)
HCV Protease (2)
PTEN (2)
IRE1 (2)
PDK (2)
RIP kinase (2)
Calcium Channel (2)
Interleukin (2)
GRK (2)
Myosin (2)
Topoisomerase (2)
Virus Protease (2)
Phospholipase (2)
IRAK (2)
Prostaglandin Receptor (1)
Pim (1)
transporter (1)
Sigma receptor (1)
Serotonin Transporter (1)
Reverse Transcriptase (1)
ROR (1)
Serine Protease (1)
IFNAR (1)
PAD (1)
cell cycle arrest (1)
Estrogen Receptor/ERR (1)
Epigenetic Reader Domain (1)
E1/E2/E3 Enzyme (1)
DUB (1)
DNA Alkylation (1)
DHFR (1)
CXCR (1)
CRISPR/Cas9 (1)
Carbonic Anhydrase (1)
FAAH (1)
Beta Amyloid (1)
BCRP (1)
Aryl Hydrocarbon Receptor (1)
Antiviral (1)
Antioxidant (1)
Antifolate (1)
AMPK (1)
AhR (1)
Estrogen/progestogen Receptor (1)
Gap Junction Protein (1)
p97 (1)
LRRK2 (1)
Nucleoside Antimetabolite/Analog (1)
Norepinephrine (1)
NAMPT (1)
NADPH (1)
Na+/Ca2+ Exchanger (1)
Monoamine Transporter (1)
Mitochondrial Metabolism (1)
MAO (1)
LDL (1)
Glucokinase (1)
Integrin (1)
IL Receptor (1)
HSV (1)
Histone Methyltransferase (1)
Histone Acetyltransferase (1)
Hedgehog/Smoothened (1)
Haspin Kinase (1)
GluR (1)
YAP (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE