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Ubiquitination Compound Library

Catalog No. L8600
  Library Compound List   Excel SDF

Ubiquitination involves covalent attachment of ubiquitin, a small 8-kDa protein, to a substrate and results in recognition and shuttling of the substrate to the 26S proteasome complex for degradation. Ubiquitination, the structured degradation and turnover of cellular proteins, is regulated by the ubiquitin–proteasome system (UPS). The ubiquitination process is tightly controlled by three families of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and finally ubiquitin ligases (E3s). Ubiquitination affects cellular process (apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc.) by regulating the degradation of proteins (via the proteasome and lysosome), coordinating the cellular localization of proteins, activating and inactivating proteins, and modulating protein-protein interactions. The ubiquitin pathway has been implicated in the pathogenesis of several diseases and genetic disorders: cancer, cardiovascular disease, and neurodegenerative disorders, etc. Recent advances in our understanding of the role and molecular mechanisms of UPS components in disease – mainly DUBs and E3 ligases, the development of high-quality chemical tools and novel inhibitors, as well as preclinical studies demonstrating chemical tractability and therapeutic potential – have dramatically taken the ubiquitin proteasome system from an improbable target class, to one of the most robust and exciting arenas for the discovery of novel drugs.

TargetMol’s Ubiquitination Compound Library collects 214 ubiquitination related small molecules, targeting proteasome, E1/E2/E3 Enzyme, DUB, p97, etc.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening;
  • Targets include proteasome, E1/E2/E3 Enzyme, DUB, p97, etc.;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L8600)

Library Composition

Proteasome (30)
p53 (29)
DUB (26)
Mdm2 (24)
DPP-4 (16)
E1/E2/E3 Enzyme (12)
Apoptosis (7)
NF-κB (7)
Cysteine Protease (6)
Sirtuin (6)
p97 (6)
Deubiquitinase (5)
IκB/IKK (3)
TNF (3)
Caspase (3)
BCL (3)
Epigenetic Reader Domain (3)
p38 MAPK (2)
HDAC (2)
PARP (2)
PPAR (2)
Serine Protease (2)
STAT (2)
IAP (2)
ERK (2)
CDK (2)
Cell wall (2)
Bcr-Abl (2)
Antibiotic (2)
Autophagy (1)
Potassium Channel (1)
Prostaglandin Receptor (1)
HCV Protease (1)
Retinoid Receptor (1)
PKC (1)
Antioxidant (1)
Src (1)
AMPK (1)
Syk (1)
TAM Receptor (1)
SARS-CoV (1)
Carbonic Anhydrase (1)
PDE (1)
BMI-1 (1)
Dehydrogenase (1)
NMDAR (1)
DNA Alkylator/Crosslinker (1)
NEDD8 (1)
MMP (1)
Mitophagy (1)
DNA Methyltransferase (1)
DNA/RNA Synthesis (1)
IGF-1R (1)
Amino Acids and Derivatives (1)
HSP (1)
HIV Protease (1)
Akt (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE