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LTX-315

Catalog No. T6881 CAS 1345407-05-7

Synonyms: LTX315, Oncopore, K-K-W-W-K-K-W-Dip-K-NH2

LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LTX-315, CAS 1345407-05-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 62.00
2 mg	In stock	$ 88.00
5 mg	In stock	$ 126.00
10 mg	In stock	$ 215.00
25 mg	In stock	$ 393.00
50 mg	Inquiry	$ 585.00

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Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
Targets&IC50	A20:8.3 μM, AT84:11 μM, MRC5:34.3 μM
In vitro	LTX-315 is highly active against both murine and human melanoma cell lines in vitro. while displaying low EC50 cytotoxic activity against human red blood cells. LTX-315 has been shown to induce the release of ATP and HMGB1 in vitro, both being DAMPs involved in ICD[1].
In vivo	when syngeneic B16 melanomas are treated intralesionally, a majority of the animals (~80%) treated with LTX-315 experience a complete and long-lasting tumor regression. LTX-315 injection induces an extensive hemorrhagic necrosis of the tumor parenchyma and a massive infiltration of CD3+ T cells, indicating that the peptide induces a type of cell death that leads to an increase in the number of tumor-infiltrating lymphocytes (TILs). treatment of a single tumor with LTX-315 generates a systemic anti-tumor immune response that eradicated distant lesions and prevented reoccurrence following tumor rechallenge[1].
Cell Research	LTX-315 is prepared in FBS-free culture medium.Tumor cells are incubated for 4 hours with 10 concentrations of LTX-315 in 1/4 dilution step with a top dose of 400 μM, with 1% (final concentration) Triton X-100 as positive control and FBS-free culture medium as negative control. Cell cytotoxicity is measured using the MTS assay
Animal Research	LTX-315 is dissolved in saline.Mice: Tumor cells are harvested, ished in RPMI-1640 and injected intradermally (i.d.) into the right side of the abdomen in C57BL/6 mice. Palpable tumors are injected i.t. with single doses of LTX-315 or LTX-328 dissolved in saline (1.0 mg peptide/50 μL saline) once a day for 3 consecutive days, and the vehicle control is saline only (0.9% NaCl in sterile water). Tumor size is measured using an electronic caliper

Synonyms	LTX315, Oncopore, K-K-W-W-K-K-W-Dip-K-NH2
Molecular Weight	1439.79
Formula	C78H106N18O9
CAS No.	1345407-05-7

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

References and Literature

1. Camilio KA ,et al. Oncoimmunology. 2014, 3: e29181. 2. Paal Brunsvig, et al. J Clin Oncol.2014, 32:5s. 3. Wang M, Ye F, Su J, et al. Caspofungin and LTX-315 inhibit SARS-CoV-2 replication by targeting the nsp12 polymerase[J]. 2020

Related compound libraries

This product is contained In the following compound libraries：

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Tanshinone IIB BI-3812 Mcl-1 inhibitor 3 Ginsenoside F4 Rasagiline A09-003 Diphenyl disulfide TCPOBOP

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LTX-315 1345407-05-7 Apoptosis BCL LTX 315 LTX315 Oncopore K-K-W-W-K-K-W-Dip-K-NH2 inhibitor inhibit

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