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Anti-CD69 Monoclonal Antibody-AF555
Anti-CD69 Monoclonal Antibody-AF555
Anti-CD69 Monoclonal Antibody-AF555 is a biotin-conjugated rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody-AF555 can be used in ELISA, FACS.
Catalog No. TMAZ-0384A5
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Anti-CD69 Monoclonal Antibody-AF555
Catalog No. TMAZ-0384A5Alias MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule
Anti-CD69 Monoclonal Antibody-AF555 is a biotin-conjugated rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody-AF555 can be used in ELISA, FACS.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Antigen Details
Chemical Properties
| Description | Anti-CD69 Monoclonal Antibody-AF555 is a biotin-conjugated rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody-AF555 can be used in ELISA, FACS. |
| Alias | MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD69 overexpressed 454F cells with TMAZ-0384A5, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD69 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Acts also via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P. aeruginosa infection. Mechanistically, specifically recognizes P. aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481) |
| Others Formats | Biotin/APC/PE/AF488/AF647 |
| Antibody Types Available | 4 |
| Immunogen | CD69 |
| Antigen Species | Human |
| Gene ID | 969 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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