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Anti-CD71 Monoclonal Antibody-APC

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Catalog No. TMAZ-0133A
Alias Transferrin receptor protein 1, T9, p90

Anti-CD71 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody-APC can be used in ELISA, FACS.

Anti-CD71 Monoclonal Antibody-APC

Anti-CD71 Monoclonal Antibody-APC

😃Good
Catalog No. TMAZ-0133AAlias Transferrin receptor protein 1, T9, p90
Anti-CD71 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody-APC can be used in ELISA, FACS.
Pack SizePriceAvailabilityQuantity
25 μg$24512 days
50 μg$40512 days
100 μg$60512 days
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Product Introduction

Bioactivity
Description
Anti-CD71 Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody-APC can be used in ELISA, FACS.
AliasTransferrin receptor protein 1, T9, p90
Ig Type
Rabbit monoclonal IgG
Reactivity
Human
Verified Activity
Flow cytometry analysis of Jurkat cells with TMAZ-0133ABI, followed by goat anti-rabbit IgG-ABflo 647 (red). The isotype control is rabbit IgG (black line).
Application
ELISA, FACS
Recommended Dose
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationSingle-pass type I membrane
ConstructionThis antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD71 protein.
PurificationProtein A Affinity Purified
AppearanceLiquid
Formulation0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
Purity> 95% as determined by SDS-PAGE.
Research BackgroundCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed: 26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed: 26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed: 26214738). When dietary levels of stearate (C18: 0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed: 26214738). When dietary levels of stearate (C18: 0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed: 26214738)|(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus
Related Conjugates and Formulations
Conjucates
APC
Others Formats
Biotin/PE/AF488/AF555/AF647
Antibody Types Available
3
Antigen Details
Immunogen
CD71
Antigen Species
Human
Gene ID
7037
Uniprot ID
Biology Area
Cancer Research
Chemical Properties
Molecular Weight150 kDa
Stability & Storage
Stability & StorageFor unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
TransportFor unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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