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Anti-CLU Monoclonal Antibody-AF555

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Catalog No. TMAZ-0178A5
Alias Testosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein

Anti-CLU Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-AF555 can be used in ELISA, FACS, IF.

Anti-CLU Monoclonal Antibody-AF555

Anti-CLU Monoclonal Antibody-AF555

😃Good
Catalog No. TMAZ-0178A5Alias Testosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein
Anti-CLU Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-AF555 can be used in ELISA, FACS, IF.
Pack SizePriceAvailabilityQuantity
25 μg52 €12 days
50 μg90 €12 days
100 μg133 €12 days
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Product Introduction

Bioactivity
Description
Anti-CLU Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-AF555 can be used in ELISA, FACS, IF.
AliasTestosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein
Ig Type
Rabbit monoclonal IgG
Reactivity
Human
Verified Activity
Flow cytometry analysis of CLU overexpressed 355F cells with TMAZ-0178A5, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
Application
ELISA, FACS, IF
Recommended Dose
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationSingle-pass type I membrane
ConstructionThis antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CLU protein.
PurificationProtein A Affinity Purified
AppearanceLiquid
Formulation0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
Purity> 95% as determined by SDS-PAGE.
Research BackgroundFunctions as extracellular chaperone that prevents aggregation of non native proteins (PubMed: 11123922, PubMed: 19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed: 11123922, PubMed: 12176985, PubMed: 17260971, PubMed: 19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed: 12047389, PubMed: 17407782, PubMed: 17412999). Does not require ATP (PubMed: 11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed: 11123922). Does not refold proteins by itself (PubMed: 11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed: 21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed: 2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed: 20068069). Modulates NF-kappa-B transcriptional activity (PubMed: 12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed: 16113678, PubMed: 17689225). Plays a role in the regulation of cell proliferation (PubMed: 19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed: 22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity)|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed: 21567405)
Related Conjugates and Formulations
Conjucates
AF555
Others Formats
Biotin/APC/PE/AF488/AF647
Antibody Types Available
3
Antigen Details
Immunogen
CLU
Antigen Species
Human
Gene ID
1191
Uniprot ID
Biology Area
Drug Target
Chemical Properties
Molecular Weight150 kDa
Stability & Storage
Stability & StorageFor unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
TransportFor unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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