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Anti-IL13 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $570 | 12 days | |
50 μg | $945 | 12 days | |
100 μg | $1,415 | 12 days |
Description | Anti-IL13 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
Alias | Interleukin-13 |
Ig Type | Rabbit monoclonal IgG |
Reactivity | Human |
Verified Activity | Flow cytometry analysis of IL13 overexpressed 382F cells with TMAZ-0022A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
Application | ELISA, FACS, IF |
Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Subcellular Localization | Single-pass type I membrane |
Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL13 protein. |
Purification | Protein A Affinity Purified |
Appearance | Liquid |
Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
Purity | > 95% as determined by SDS-PAGE. |
Research Background | Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed: 8096327, PubMed: 8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed: 8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed: 7903680, PubMed: 8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed: 8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed: 9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed: 21622864) |
Conjucates | AF488 |
Others Formats | Biotin/APC/PE/AF555/AF647 |
Antibody Types Available | 2 |
Immunogen | IL13 |
Antigen Species | Human |
Gene ID | 3596 |
Uniprot ID | |
Biology Area | Immunology Research |
Molecular Weight | 150 kDa |
Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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