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Anti-IL1R1 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting IL1R1. Anti-IL1R1 Monoclonal Antibody-AF555 can be used in ELISA, FACS.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $570 | 12 days | |
50 μg | $945 | 12 days | |
100 μg | $1,415 | 12 days |
Description | Anti-IL1R1 Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting IL1R1. Anti-IL1R1 Monoclonal Antibody-AF555 can be used in ELISA, FACS. |
Alias | p80, Interleukin-1 receptor type I, Interleukin-1 receptor type 1, Interleukin-1 receptor alpha, CD121 antigen-like family member A |
Ig Type | Rabbit monoclonal IgG |
Reactivity | Human |
Verified Activity | Flow cytometry analysis of IL1R1 overexpressed 483F cells with TMAZ-0067A5, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
Application | ELISA, FACS |
Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Subcellular Localization | Single-pass membrane protein |
Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL1R1 protein. |
Purification | Protein A Affinity Purified |
Appearance | Liquid |
Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
Purity | > 95% as determined by SDS-PAGE. |
Research Background | Receptor for IL1A, IL1B and IL1RN (PubMed: 2950091, PubMed: 37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed: 10653850) |
Conjucates | AF555 |
Others Formats | Biotin/APC/PE/AF488/AF647 |
Antibody Types Available | 1 |
Immunogen | IL1R1 |
Antigen Species | Human |
Gene ID | 3554 |
Uniprot ID | |
Biology Area | Immunology Research |
Molecular Weight | 150 kDa |
Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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