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Anti-IL6R Monoclonal Antibody-AF488
Anti-IL6R Monoclonal Antibody-AF488
Anti-IL6R Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody-AF488 can be used in FACS.
Catalog No. TMAZ-0053A4
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Anti-IL6R Monoclonal Antibody-AF488
Catalog No. TMAZ-0053A4Alias Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1
Anti-IL6R Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody-AF488 can be used in FACS.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $330 | 12 days | |
| 50 μg | $550 | 12 days | |
| 100 μg | $820 | 12 days |
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL6R Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody-AF488 can be used in FACS. |
| Alias | Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of IL-6R overexpressed 293F cells with TMAZ-0053A4BI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL-6R protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed: 28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed: 30995492, PubMed: 31235509). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6: IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable)|Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity)|Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed: 21990364). The IL6: sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed: 21990364). In complex with IL6, is required for induction of VEGF production (PubMed: 12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)|Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed: 21990364). The IL6: sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed: 21990364). In complex with IL6, is required for induction of VEGF production (PubMed: 12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | IL-6R |
| Antigen Species | Human |
| Gene ID | 3570 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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