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Anti-IL6R Monoclonal Antibody-APC
Catalog No. TMAZ-0053A
Alias Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1
Anti-IL6R Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody-APC can be used in FACS.
Anti-IL6R Monoclonal Antibody-APC
Anti-IL6R Monoclonal Antibody-APC
Catalog No. TMAZ-0053AAlias Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1
Anti-IL6R Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody-APC can be used in FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $330 | 12 days | |
| 50 μg | $550 | 12 days | |
| 100 μg | $820 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL6R Monoclonal Antibody-APC is a Biotin-conjugated rabbit antibody targeting IL6R. Anti-IL6R Monoclonal Antibody-APC can be used in FACS. |
| Alias | Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6R 1 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of IL-6R overexpressed 293F cells with TMAZ-0053ABI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL-6R protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed: 28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed: 30995492, PubMed: 31235509). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6: IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable)|Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity)|Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed: 21990364). The IL6: sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed: 21990364). In complex with IL6, is required for induction of VEGF production (PubMed: 12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)|Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed: 21990364). The IL6: sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed: 21990364). In complex with IL6, is required for induction of VEGF production (PubMed: 12794819). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity) |
| Conjucates | APC |
| Others Formats | Biotin/PE/AF488/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | IL-6R |
| Antigen Species | Human |
| Gene ID | 3570 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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