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Anti-IL6ST Monoclonal Antibody-AF488
Catalog No. TMAZ-0043A4
Alias Oncostatin-M receptor subunit alpha, Membrane glycoprotein 130, Interleukin-6 signal transducer, Interleukin-6 receptor subunit beta, CDw130
Anti-IL6ST Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Anti-IL6ST Monoclonal Antibody-AF488
Anti-IL6ST Monoclonal Antibody-AF488
Catalog No. TMAZ-0043A4Alias Oncostatin-M receptor subunit alpha, Membrane glycoprotein 130, Interleukin-6 signal transducer, Interleukin-6 receptor subunit beta, CDw130
Anti-IL6ST Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $430 | 12 days | |
| 50 μg | $715 | 12 days | |
| 100 μg | $1,070 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL6ST Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| Alias | Oncostatin-M receptor subunit alpha, Membrane glycoprotein 130, Interleukin-6 signal transducer, Interleukin-6 receptor subunit beta, CDw130 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of IL6ST overexpressed 293F cells with TMAZ-0043A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL6ST protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Signal-transducing molecule (PubMed: 2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed: 19915009, PubMed: 2261637, PubMed: 23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed: 19915009, PubMed: 23294003, PubMed: 25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed: 19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity)|Binds to the soluble IL6: sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed: 11121117, PubMed: 21990364, PubMed: 30279168). Also blocks IL11 cluster signaling through IL11R (PubMed: 30279168) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | IL6ST |
| Antigen Species | Human |
| Gene ID | 3572 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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