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Anti-LILRB4 Monoclonal Antibody-AF488
Catalog No. TMAZ-0181A4
Alias Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K
Anti-LILRB4 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-LILRB4 Monoclonal Antibody-AF488
Anti-LILRB4 Monoclonal Antibody-AF488
Catalog No. TMAZ-0181A4Alias Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K
Anti-LILRB4 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-LILRB4 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| Alias | Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of LILRB4 overexpressed 351F cells with TMAZ-0181A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LILRB4 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed: 11875462). Receptor for FN1 (PubMed: 34089617). Receptor for apolipoprotein APOE (PubMed: 30333625). Receptor for ALCAM/CD166 (PubMed: 29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed: 9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed: 19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed: 34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed: 16493035, PubMed: 19833736, PubMed: 29263213). Induces up-regulation of CD86 on dendritic cells (PubMed: 19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed: 11875462) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 2 |
| Immunogen | LILRB4 |
| Antigen Species | Human |
| Gene ID | 11006 |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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