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Anti-LTF Monoclonal Antibody-AF488
Catalog No. TMAZ-0136A4
Alias Talalactoferrin, Lactotransferrin, Growth-inhibiting protein 12
Anti-LTF Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting LTF. Anti-LTF Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-LTF Monoclonal Antibody-AF488
Anti-LTF Monoclonal Antibody-AF488
Catalog No. TMAZ-0136A4Alias Talalactoferrin, Lactotransferrin, Growth-inhibiting protein 12
Anti-LTF Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting LTF. Anti-LTF Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-LTF Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting LTF. Anti-LTF Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| Alias | Talalactoferrin, Lactotransferrin, Growth-inhibiting protein 12 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of LTF overexpressed 460F cells with TMAZ-0136A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LTF protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate|Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions (PubMed: 11179314, PubMed: 12693969, PubMed: 14573629, PubMed: 1599934, PubMed: 3169987, PubMed: 6802759). Has antimicrobial activity, which depends on the extracellular cation concentration (PubMed: 6802759). Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane (PubMed: 11179314, PubMed: 12693969, PubMed: 14573629, PubMed: 1599934, PubMed: 3169987, PubMed: 6802759). Can also prevent bacterial biofilm development in P.aeruginosa infection (PubMed: 12037568). Has weak antifungal activity against C.albicans (PubMed: 11083624). Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth (PubMed: 15166119). Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection (PubMed: 17079302). Can inhibit papillomavirus infections (PubMed: 17481742). Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling (PubMed: 20345905). Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells (PubMed: 19033648). Stimulates VEGFA-mediated endothelial cell migration and proliferation (PubMed: 16842782). Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs) (PubMed: 9359845). Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA (PubMed: 9359845)|Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection (PubMed: 17481742). N-terminal region shows strong antifungal activity against C.albicans (PubMed: 11083624). Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site|Has antimicrobial activity and is able to permeabilize different ions through liposomal membranes|Has opioid antagonist activity (PubMed: 1369293). Shows preference for mu-receptor (PubMed: 1369293)|Has opioid antagonist activity (PubMed: 1369293). Shows higher degrees of preference for kappa-receptors than for mu-receptors (PubMed: 1369293)|Has opioid antagonist activity (PubMed: 1369293). Shows higher degrees of preference for kappa-receptors than for mu-receptors (PubMed: 1369293)|The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions (PubMed: 12535064). This function contributes to the antimicrobial activity (PubMed: 12535064). Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites (PubMed: 12535064)|Transcription factor with antiproliferative properties and ability to induce cell cycle arrest (PubMed: 15222485). Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters (PubMed: 22320386) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | LTF |
| Antigen Species | Human |
| Gene ID | 4057 |
| Uniprot ID | |
| Biology Area | Cancer Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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