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Anti-NPC2 Monoclonal Antibody-AF488
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Catalog No. TMAZ-0065A4
Alias NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Human epididymis-specific protein 1, Epididymal secretory protein E1
Anti-NPC2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-NPC2 Monoclonal Antibody-AF488
Anti-NPC2 Monoclonal Antibody-AF488
😃Good
Catalog No. TMAZ-0065A4Alias NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Human epididymis-specific protein 1, Epididymal secretory protein E1
Anti-NPC2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-NPC2 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting NPC2. Anti-NPC2 Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| Alias | NPC intracellular cholesterol transporter 2, Niemann-Pick disease type C2 protein, Human epididymis-specific protein 1, Epididymal secretory protein E1 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of NPC2 overexpressed 476F cells with TMAZ-0065A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of NPC2 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed: 11125141, PubMed: 15937921, PubMed: 17018531, PubMed: 18772377, PubMed: 29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed: 17018531, PubMed: 18772377, PubMed: 27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed: 18823126). NPC2 binds cholesterol with a 1: 1 stoichiometry (PubMed: 17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed: 17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | NPC2 |
| Antigen Species | Human |
| Gene ID | 10577 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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