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Anti-PD-L1 Monoclonal Antibody-AF488

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Catalog No. TMAZ-0055A4
Alias Programmed cell death 1 ligand 1, B7 homolog 1

Anti-PD-L1 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.

Anti-PD-L1 Monoclonal Antibody-AF488

Anti-PD-L1 Monoclonal Antibody-AF488

😃Good
Catalog No. TMAZ-0055A4Alias Programmed cell death 1 ligand 1, B7 homolog 1
Anti-PD-L1 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Pack SizePriceAvailabilityQuantity
25 μg$36512 days
50 μg$60512 days
100 μg$90512 days
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Product Introduction

Bioactivity
Description
Anti-PD-L1 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
AliasProgrammed cell death 1 ligand 1, B7 homolog 1
Ig Type
Rabbit monoclonal IgG
Reactivity
Human
Verified Activity
Flow cytometry analysis of PD-L1 overexpressed 293F cells with TMAZ-0055A4BI, which was counjucated with SA-PE (red). The WT 293F control is black line.
Application
ELISA, FACS, IF
Recommended Dose
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted
ConstructionThis antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PD-L1 protein.
PurificationProtein A Affinity Purified
AppearanceLiquid
Formulation0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
Purity> 95% as determined by SDS-PAGE.
Research BackgroundPlays a critical role in induction and maintenance of immune tolerance to self (PubMed: 11015443, PubMed: 28813410, PubMed: 28813417, PubMed: 31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed: 11015443, PubMed: 28813410, PubMed: 28813417, PubMed: 36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed: 10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed: 32929201)|The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed: 28813410, PubMed: 28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity)
Related Conjugates and Formulations
Conjucates
AF488
Others Formats
Biotin/APC/PE/AF555/AF647
Antibody Types Available
1
Antigen Details
Immunogen
PD-L1
Antigen Species
Human
Gene ID
29126
Uniprot ID
Biology Area
Immunology Research
Chemical Properties
Molecular Weight150 kDa
Stability & Storage
Stability & StorageFor unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
TransportFor unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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