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Anti-PD-L1 Monoclonal Antibody-AF647
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Catalog No. TMAZ-0055A6
Alias Programmed cell death 1 ligand 1, B7 homolog 1
Anti-PD-L1 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
Anti-PD-L1 Monoclonal Antibody-AF647
Anti-PD-L1 Monoclonal Antibody-AF647
😃Good
Catalog No. TMAZ-0055A6Alias Programmed cell death 1 ligand 1, B7 homolog 1
Anti-PD-L1 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $365 | 12 days | |
| 50 μg | $605 | 12 days | |
| 100 μg | $905 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PD-L1 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting PD-L1. Anti-PD-L1 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF. |
| Alias | Programmed cell death 1 ligand 1, B7 homolog 1 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of PD-L1 overexpressed 293F cells with TMAZ-0055A6BI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PD-L1 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed: 11015443, PubMed: 28813410, PubMed: 28813417, PubMed: 31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed: 11015443, PubMed: 28813410, PubMed: 28813417, PubMed: 36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed: 10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed: 32929201)|The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed: 28813410, PubMed: 28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity) |
| Conjucates | AF647 |
| Others Formats | Biotin/APC/PE/AF488/AF555 |
| Antibody Types Available | 1 |
| Immunogen | PD-L1 |
| Antigen Species | Human |
| Gene ID | 29126 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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