Vupanorsen sodium

Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide designed to inhibit the synthesis of Angiopoietin-like 3 (ANGPTL3) protein. This compound effectively reduces levels of triglycerides and atherogenic lipoproteins.

Catalog No. T87626Cas No. 2172852-12-7

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Vupanorsen sodium

Catalog No. T87626Cas No. 2172852-12-7

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Product Introduction

Bioactivity

Description	Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide designed to inhibit the synthesis of Angiopoietin-like 3 (ANGPTL3) protein. This compound effectively reduces levels of triglycerides and atherogenic lipoproteins.
Alias	IONIS ANGPT-L3Rx sodium, ISIS 703802 sodium

Chemical Properties

Molecular Weight	9105.04
Formula	C₂₉₆H₄₁₄N₈₆Na₂₀O₁₅P₂₀S₁₃
Cas No.	2172852-12-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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