Shopping Cart

Remove All

Your shopping cart is currently empty

CDK4/6-IN-6

Select Batch

Purity:95.63%

Resource Download

COA HPLC HNMR

CDK4/6-IN-6

Catalog No. T39957Cas No. 2380321-51-5

CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$115	In Stock
5 mg	$247	In Stock
10 mg	$397	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
100 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$287	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "CDK4/6-IN-6"

Product Introduction

Bioactivity

Description	CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
In vitro	CDK4/6-IN-6 (example A94) has IC 50 s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

Chemical Properties

Molecular Weight	463.93
Formula	C22H27ClFN5O3
Cas No.	2380321-51-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (118.55 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1555 mL	10.7775 mL	21.5550 mL	107.7749 mL
5 mM	0.4311 mL	2.1555 mL	4.3110 mL	21.5550 mL
10 mM	0.2155 mL	1.0777 mL	2.1555 mL	10.7775 mL
20 mM	0.1078 mL	0.5389 mL	1.0777 mL	5.3887 mL
50 mM	0.0431 mL	0.2155 mL	0.4311 mL	2.1555 mL
100 mM	0.0216 mL	0.1078 mL	0.2155 mL	1.0777 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc