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Cell Cycle/Checkpoint ROCK Hydroxyfasudil Hydrochloride

Hydroxyfasudil Hydrochloride

Catalog No. T4276   CAS 155558-32-0
Synonyms: HA 1100 hydrochloride, Hydroxyfasudil (HA-1100) HCl
Purity 99.82% Datasheet

Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).

Hydroxyfasudil Hydrochloride, CAS 155558-32-0
Pack Size Availability Price/USD Quantity
2 mg In stock 48.00
5 mg In stock 68.00
10 mg In stock 99.00
50 mg In stock 176.00
100 mg In stock 320.00
1 mL * 10 mM (in DMSO) In stock 74.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
Targets&IC50 ROCK,  
In vitro Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats
Animal Research
Hydroxyfasudil is formulated in saline. Micturition behavior is studied after administration of either Hydroxyfasudil (10 mg/kg, i.p.) or a corresponding volume of saline. Each rat is placed in a metabolic cage containing a urine collection funnel that is placed over an electronic balance. The balance is connected to a personal computer via a multiport controller and used to measure the cumulative weight of the collected urine. Every 150 s during a continuous 24-h period, the computer samples and records the data for the micturition frequency and volumes. The micturition reflex parameters that are collected include: urine volume per micturition, maximal micturition volume, micturition frequency, and total urine output in the Hydroxyfasudil- or vehicle-treated animals. Each monitoring session started at 18.00 hours. Prior to being placed in the metabolic cage at the start of each experimental period, the animals received either a single injection of Hydroxyfasudil (10 mg/kg) dissolved in saline or an injection of saline without the inhibitor.
Synonyms HA 1100 hydrochloride, Hydroxyfasudil (HA-1100) HCl
Purity 99.82%
Appearance solid
Molecular Weight 343.83
Formula C14H18ClN3O3S
CAS No. 155558-32-0

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 62 mg/mL (180.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1. 2. Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7. 3. Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66(4):325-31.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-cancer Compound Library

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