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Methiothepin maleate

Catalog No. T4375 CAS 19728-88-2

Synonyms: 甲替平, Metitepine

Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

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Methiothepin maleate, CAS 19728-88-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
Targets&IC50	h5-HT(7) receptor:152 nM
In vivo	The intracerebroventricular administration of aftin-4 (3–20 nmol) increased Aβ1-42, but not Aβ1-40, content in the mouse hippocampus, between 5 and 14 days after injection. Aftin-4 injection increased lipid peroxidation levels in the hippocampus, an index of oxidative stress.

Synonyms	甲替平, Metitepine
Molecular Weight	472.62
Formula	C24H28N2O4S2
CAS No.	19728-88-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Knight J A, etal. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists[J]. Molecular Pharmacology, 2009, 75(2):374-380. 2. Rizviä E, etal. Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors[J]. Bosn J Basic Med Sci, 2017, 17(3):194-202.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Methiothepin maleate 19728-88-2 G蛋白偶联受体神经科学 5-HT Receptor Metitepine Inhibitor inhibitor inhibit

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