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Tyrosine Kinase/Adaptors IGF-1R TAE226

TAE226

Catalog No. T1918   CAS 761437-28-9
Synonyms: NVP-TAE 226
Purity 99.17% Datasheet

NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.

TAE226, CAS 761437-28-9
Pack Size Availability Price/USD Quantity
2 mg In stock 64.00
5 mg In stock 116.00
10 mg In stock 185.00
25 mg In stock 405.00
50 mg In stock 767.00
100 mg In stock 1271.00
1 mL * 10 mM (in DMSO) In stock 116.00
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Biological Description
Chemical Properties
Storage & Solubility Information
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Description NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.
Targets&IC50 c-Met :ic50 160nM,   FAK :ic50 5.5nM,   IGF-1R :ic50 140nM,   Insulin Receptor :ic50 43.5nM,   PYK2 :ic50 3.5nM,  
Cell Research
Cell cultures are harvested with 0.05% trypsin and seeded in triplicate at 2 × 104 in 24-well culture plates for 24 h before drug treatment. Culture medium is used for mock treatment. Cells are harvested at the indicated day after treatment, and viable cells are counted using the Vi-cell viability analyze(Only for Reference)
Cell lines: U87 and U251 cell lines
Animal Research
Animal Model: nude mice bearing intracranial glioma xenografts
Synonyms NVP-TAE 226
Purity 99.17%
Appearance solid
Molecular Weight 468.94
Formula C23H25ClN6O3
CAS No. 761437-28-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 87 mg/mL (185.5 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

0.5% methylcellulose: 30 mg/mL

Citations

References and Literature
1. Liu TJ, et al. Mol Cancer Ther, 2007, 6(4), 1357-1367. 2. Beierle EA, et al. Cancer Invest, 2008, 26(2), 145-151. 3. Schultze A, et al. Invest New Drugs, 2010, 28(6), 825-833. 4. Hatakeyama S, et al. 2006, ASCO Annual Meeting. Abst 13162. 5. Kawahara E, et al. 2006, ASCO Annual Meeting. Abst 13163.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Tyrosine kinase inhibitor library Kinase Inhibitor Library Angiogenesis related Compound Library

Related Products

Related compounds with same targets
LDK378 TAE226 PQ401 BMS-754807 PD173074 AG1024 AP26113 GSK1838705A

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