Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thalidomide-O-amido-C8-NH2 hydrochloride is a synthetic conjugate of an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide and a linker. It can be utilized in the synthesis of PROTACs[1].
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Description | Thalidomide-O-amido-C8-NH2 hydrochloride is a synthetic conjugate of an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide and a linker. It can be utilized in the synthesis of PROTACs[1]. |
In vitro | Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[1]. |
Synonyms | Thalidomide-O-amido-C8-NH2 hydrochloride (1950635-15-0 free base) |
Molecular Weight | 494.97 |
Formula | C23H31ClN4O6 |
CAS No. | T18817 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Thalidomide-O-amido-C8-NH2 hydrochloride T18817 Others Thalidomide-O-amido-C-8-NH2 hydrochloride Thalidomide O amido C8 NH2 hydrochloride 1950635-15-0 Thalidomide-O-amido-C8-NH2 Hydrochloride 1950635-15-0 free base Thalidomide-O-amido-C8-NH2 hydrochloride (1950635-15-0 free base) ThalidomideOamidoC8NH2 hydrochloride inhibitor inhibit