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Anti-CD33 Monoclonal Antibody-PE
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Catalog No. TMAZ-0119P
Alias Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67
Anti-CD33 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-PE can be used in ELISA, FACS, IF.
Anti-CD33 Monoclonal Antibody-PE
Anti-CD33 Monoclonal Antibody-PE
😃Good
Catalog No. TMAZ-0119PAlias Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67
Anti-CD33 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-PE can be used in ELISA, FACS, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $285 | 12 days | |
| 50 μg | $475 | 12 days | |
| 100 μg | $715 | 12 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD33 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-PE can be used in ELISA, FACS, IF. |
| Alias | Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD33 overexpressed 340F cells with TMAZ-0119P, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS, IF |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD33 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed: 10611343, PubMed: 11320212, PubMed: 15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 10887109, PubMed: 28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed: 10206955, PubMed: 10556798, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed: 15597323) |
| Conjucates | PE |
| Others Formats | Biotin/APC/AF488/AF555/AF647 |
| Antibody Types Available | 3 |
| Immunogen | CD33 |
| Antigen Species | Human |
| Gene ID | 945 |
| Uniprot ID | |
| Biology Area | Cancer Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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