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Anti-CD69 Monoclonal Antibody-APC
Catalog No. TMAZ-0384A
Alias MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule
Anti-CD69 Monoclonal Antibody-APC is a biotin-conjugated rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody-APC can be used in ELISA, FACS.
Anti-CD69 Monoclonal Antibody-APC
Anti-CD69 Monoclonal Antibody-APC
Catalog No. TMAZ-0384AAlias MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule
Anti-CD69 Monoclonal Antibody-APC is a biotin-conjugated rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody-APC can be used in ELISA, FACS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Concentration:0.27 mg/mL
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD69 Monoclonal Antibody-APC is a biotin-conjugated rabbit antibody targeting CD69. Anti-CD69 Monoclonal Antibody-APC can be used in ELISA, FACS. |
| Alias | MLR-3, Leukocyte surface antigen Leu-23, GP32/28, Early T-cell activation antigen p60, Early activation antigen CD69, EA1, C-type lectin domain family 2 member C, BL-AC/P26, Activation inducer molecule |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD69 overexpressed 454F cells with TMAZ-0384A, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD69 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Acts also via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P. aeruginosa infection. Mechanistically, specifically recognizes P. aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481) |
| Others Formats | Biotin/PE/AF488/AF555/AF647 |
| Antibody Types Available | 4 |
| Immunogen | CD69 |
| Antigen Species | Human |
| Gene ID | 969 |
| Uniprot ID | |
| Biology Area | Immunology Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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