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Anti-DCD Monoclonal Antibody-AF488
Anti-DCD Monoclonal Antibody-AF488
Anti-DCD Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting DCD. Anti-DCD Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Catalog No. TMAZ-0265A4
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Anti-DCD Monoclonal Antibody-AF488
Catalog No. TMAZ-0265A4Alias Preproteolysin, Dermcidin
Anti-DCD Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting DCD. Anti-DCD Monoclonal Antibody-AF488 can be used in ELISA, FACS.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $570 | 12 days | |
| 50 μg | $945 | 12 days | |
| 100 μg | $1,415 | 12 days |
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Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-DCD Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting DCD. Anti-DCD Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| Alias | Preproteolysin, Dermcidin |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of DCD overexpressed 472F cells with TMAZ-0265A4, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | ELISA, FACS |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of DCD protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed: 11694882, PubMed: 23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes (PubMed: 23426625). Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival (PubMed: 23426625). Highly effective against E.coli, E.faecalis, S.aureus and C.albicans (PubMed: 11694882). Optimal pH and salt concentration resemble the conditions in sweat (PubMed: 11694882). Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed: 17448443)|Promotes survival of neurons and displays phosphatase activity (PubMed: 9736629). It may bind IgG (PubMed: 9736629) |
| Conjucates | AF488 |
| Others Formats | Biotin/APC/PE/AF555/AF647 |
| Antibody Types Available | 1 |
| Immunogen | DCD |
| Antigen Species | Human |
| Gene ID | 117159 |
| Uniprot ID | |
| Biology Area | Other Functions |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| Transport | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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