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Casimersen
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Catalog No. T38859Cas No. 1422958-19-7
Alias SRP-4045
Casimersen (SRP-4045) is an antisense oligonucleotide in the phosphorodiamidate morpholino oligomer subclass. It binds to exon 45 of dystrophin pre-mRNA, skipping the exon to restore the open-reading frame, resulting in a functional but internally truncated dystrophin protein. Casimersen is used in Duchenne muscular dystrophy (DMD) research.
Casimersen
😃Good
Catalog No. T38859Alias SRP-4045Cas No. 1422958-19-7
Casimersen (SRP-4045) is an antisense oligonucleotide in the phosphorodiamidate morpholino oligomer subclass. It binds to exon 45 of dystrophin pre-mRNA, skipping the exon to restore the open-reading frame, resulting in a functional but internally truncated dystrophin protein. Casimersen is used in Duchenne muscular dystrophy (DMD) research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $764 | Backorder | |
| 5 mg | $1,990 | Backorder | |
| 10 mg | $2,980 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Casimersen (SRP-4045) is an antisense oligonucleotide in the phosphorodiamidate morpholino oligomer subclass. It binds to exon 45 of dystrophin pre-mRNA, skipping the exon to restore the open-reading frame, resulting in a functional but internally truncated dystrophin protein. Casimersen is used in Duchenne muscular dystrophy (DMD) research. |
| In vitro | Exon 45 skipping aims to facilitate the production of a shorter, internally truncated form of dystrophin protein in patients whose genetic mutations make them suitable candidates for Exon 45 skipping[2]. |
| Alias | SRP-4045 |
| Cas No. | 1422958-19-7 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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