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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $764 | Backorder | |
5 mg | $1,990 | Backorder | |
10 mg | $2,980 | Backorder |
Description | Casimersen (SRP-4045) is an antisense oligonucleotide in the phosphorodiamidate morpholino oligomer subclass. It binds to exon 45 of dystrophin pre-mRNA, skipping the exon to restore the open-reading frame, resulting in a functional but internally truncated dystrophin protein. Casimersen is used in Duchenne muscular dystrophy (DMD) research. |
In vitro | Exon 45 skipping aims to facilitate the production of a shorter, internally truncated form of dystrophin protein in patients whose genetic mutations make them suitable candidates for Exon 45 skipping[2]. |
Alias | SRP-4045 |
Cas No. | 1422958-19-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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