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JAB-3312

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Catalog No. T200151Cas No. 2245082-05-5

JAB-3312 is an orally active anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with demonstrated antitumor activity. The compound is well-tolerated and significantly induces tumor regression in the KYSE-520 mouse xenograft model.

JAB-3312

JAB-3312

😃Good
Catalog No. T200151Cas No. 2245082-05-5
JAB-3312 is an orally active anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with demonstrated antitumor activity. The compound is well-tolerated and significantly induces tumor regression in the KYSE-520 mouse xenograft model.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
JAB-3312 is an orally active anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with demonstrated antitumor activity. The compound is well-tolerated and significantly induces tumor regression in the KYSE-520 mouse xenograft model.
Chemical Properties
Molecular Weight439.96
FormulaC21H22ClN7S
Cas No.2245082-05-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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