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PAA4

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PAA4

Catalog No. T81574

PAA4, a methide carbon-centered polynuclear Au(I) cluster, exhibits antiproliferative activity and induces pH2AX expression in a time-dependent manner. It also demonstrates an anti-tumor effect in an orthotopic bladder cancer mouse model [1].

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Product Introduction

Bioactivity

Description	PAA4, a methide carbon-centered polynuclear Au(I) cluster, exhibits antiproliferative activity and induces pH2AX expression in a time-dependent manner. It also demonstrates an anti-tumor effect in an orthotopic bladder cancer mouse model [1].
In vitro	PAA4, at concentrations ranging from 0 to 4 µM over a 24-hour period, does not exhibit notable cytotoxic effects on EJ, HUVEC, and SV-HUC-1 cell lines, with IC50 values recorded at 2.
In vivo	PAA4, administered intravesically at a concentration of 1.5 µM in a volume of 100 µL, exhibited anti-tumor effects in a murine model. The compound was delivered five times on alternating days over a span of eight days [1].

Chemical Properties

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Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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