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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,780 | 10-14 weeks | |
50 mg | $2,320 | 10-14 weeks | |
100 mg | $3,730 | 10-14 weeks |
Description | WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM). |
In vitro | In G2M phase cells, WDR5-IN-1 (1 μM; 48 hours) shows an apparent decrease . WDR5-IN-1 (0.01-3 μM; 24-48 hours) increases p53 and p21 protein levels. WDR5-IN-1 shows anti-proliferative activity in MYC-driven cancers (CHP-134, Ramos, Raji, Daudi, SW620, SW480 cells)(GI50s : 0.26-3.2 μM). |
Molecular Weight | 514.59 |
Formula | C30H31FN4O3 |
Cas No. | 2408842-51-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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