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HLA-G Free Heavy Chain Protein, Human, Recombinant (His & Avi)
Catalog No. TMPK-00836
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
HLA-G Free Heavy Chain Protein, Human, Recombinant (His & Avi)
Catalog No. TMPK-00836
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $347 | 7-10 days | |
| 500 μg | $1,400 | 7-10 days | |
| 1 mg | $2,330 | 7-10 days |
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Product Information
| Biological Activity | Immobilized Human HLA-G Free Heavy Chain, His Tag at 2μg/ml (100μl/Well) on the. Dose response curve for Anti-HLA-G Antibody, hFc Tag with the EC50 of 25.9ng/ml determined by ELISA. |
| Description | HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition. |
| Species | Human |
| Expression System | E. coli |
| Tag | C-His-Avi |
| Accession Number | P17693-1 |
| Synonyms | sHLA-G,MHC-G,MHC class Ib antigen,MHC Class I Antigen G,HLA-G,HLAG,HLA G antigen,HLA G,b2 microglobulin |
| Construction | Gly25-Thr305(C66S) |
| Protein Purity | > 95% as determined by Tris-Bis PAGE |
| Molecular Weight | 35.5 kDa (predicted). The protein migrates to 36-40 kDa based on Tris-Bis PAGE result. |
| Endotoxin | < 1 EU/μg by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in 20 mM Tris, 500 mM NaCl, 20% Glycerol (pH 8.0). |
| Stability & Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Shipping with blue ice. |
| Research Background | HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition. |
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