Immobilized LGR-5 Protein-VLP, Human, Recombinant (Flag & His-Strep) (Cat#TMPY-07172) at 5 μg/mL (100 μL/well) can bind Petosemtamab Derived Anti-CCR5 Monoclonal antibody, Human IgG1, the EC50 is 1.5-5 ng/mL.

LGR-5 Protein-VLP, Human, Recombinant (Flag & His-Strep) is expressed in HEK293 Cells. The accession number is O75473.

Human

HEK293 Cells

HG38,GRP49,GPR67,GPR49,FEX

A DNA sequence encoding the Human LGR5 -VLP (O75473) (Gly22-Ser844) was expressed, with a Flag tag at the N-terminus, a polyhistidine tag and a strep tag at the C-terminus.

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) plays a vital role in the development of malignant tumors. Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is highly expressed in colorectal tumors and marks colon cancer stem cells that drive tumor growth and metastasis. LGR5, a well-characterized marker of stem cell and cancer stem cells (CSCs), is best known as a transmembrane receptor for increases canonical Wnt signaling amplitude. LGR5 expressing cells are not limited to the postulated stem cell niche but LGR5 expression is hormonally regulated.