LSAMP Protein, Human, Recombinant (hFc)

Catalog No. TMPY-02374

LSAMP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59 kDa and the accession number is Q13449.

LSAMP Protein, Human, Recombinant (hFc)

Catalog No. TMPY-02374

LSAMP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59 kDa and the accession number is Q13449.

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100 μg	$700	7-10 days

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Product Information

Biological Activity	1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant human OPCML-His at 10 μg/mL can bind recombinant human LSAMP-Fc with a linear range of 31.25-250 ng/ml.
Description	LSAMP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59 kDa and the accession number is Q13449.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q13449
Synonyms	limbic system-associated membrane protein,LAMP,IGLON3,FLJ54658,FLJ37216,FLJ35396,FLJ34254
Construction	A DNA sequence encoding the human LSAMP (Q13449) (Met 1-Asn 315), without the pro peptide, was was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Val 29
Protein Purity	> 97 % as determined by SDS-PAGE
Molecular Weight	59 kDa (predicted); 80-85 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning, and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there has been found that rats with an increased level of anxiety had 1.6-fold higher expression of the LsAMP gene in the periaqueductal gray compared to rats with a low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.