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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $462 | 7-10 days |
Biological Information | 1. Immobilized mouse FLT4-His at 10 μg/mL (100 μL/well) can bind mouse/rat Fc-VEGFC, The EC50 of mouse/rat Fc-VEGFC is 0.41-0.95 μg/mL.
2. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is typically 70-300 ng/mL. |
Description | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 41.5 kDa and the accession number is O35757. |
Species | Mouse,Rat |
Expression System | HEK293 Cells |
Tag | N-hFc |
Accession Number | O35757 |
Synonyms | vascular endothelial growth factor C |
Construction | The Mouse / Rat VEGFC (NP_033532.1/O35757) (Ala108-Arg223) was expressed fused with the Fc region of Human IgG1 at the N-terminus. Mouse and Rat mature VEGFC sequences are identical. |
Protein Purity | > 90 % as determined by SDS-PAGE |
Molecular Weight | 41.5 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors. |
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