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Signaling Pathway Download


Product Name


Diseases and Conditions

T3634 AZD-9291 mesylate
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and p... Cancer
T3673 Mollugin
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocki... Others
T3659 AZD3759
AZD3759 is a potent, oral active, central nervous system-penetrant, EGFR inhibitor. At Km ... Cancer
T3024 Avitinib

Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epide...

T6995 STA-21
STA-21 is a selective STAT3 inhibitor. Others
T6933 Peficitinib (ASP015K, JNJ-54781532)
Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3. Others
T6932 PD168393
PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys... Others
T6918 Olmutinib (HM61713, BI 1482694)
Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-spe... Others
T6914 Oclacitinib
Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM ... Others
T6908 NSC228155
NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulat... Others
T6838 FLLL32
FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. Others
T6824 EAI045
EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants but sp... Others
T6790 BMS-911543
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1?nM, ~350-, 75- and... Others
T3402new Ginsenoside Rg3
Ginsenoside Rg3 possess an ability to inhibit the lung metastasis of tumor cells via inhib... Others
T3404new Cucurbitacin B
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human p... Others
T3620new Solcitinib
Solcitinib, also known as GSK2586184 or GLPG0778, is a Janus kinase 1 (JAK1) inhibitor. So... Immunology
T3380new Homoharringtonine
Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid m... Cancer
T3398new Icaritin
Icaritin has hormone regulation activity and cardiovascular function improvement activity.... Cancer
T3441new Anlotinib
Anlotinib is a EGFR inhibitor extracted from patent 2015185012 A1, compound 1,which can be... Cancer
T3218 Napabucasin
Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor. Other
T6669 SH-4-54
SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respe... Cancer
T6537 HO-3867
HO-3867, an analog of curcumin, is a selective STAT3 inhibitor. Cancer
T6734 WZ8040
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB... Cancer
T6733 WZ3146
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) wit... Cancer
T6719 Varlitinib
Varlitinib is a selective and potent ErbB1(EGFR) and ErbB2(HER2) inhibitor with IC50 of 7 ... Cancer
T6619 OSI-420
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an o... Cancer
T6427 Butein
Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activati... Cancer
T2501 Canertinib dihydrochloride
Canertinib Dihydrochloride is the hydrochloride salt of an orally bio-available quinazolin... Cancer
T6238 WZ4002
WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 ... Cancer
T6156 S-Ruxolitinib (INCB018424)
S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2... Cancer