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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(50)

Glyoxalase

(2)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(40)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(116)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(53)

Stearoyl-CoA Desaturase (SCD)

CETP

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride.

Filter HomeSignaling PathwaysMetabolismCETP

Obicetrapib

T28225866399-87-3In house

Obicetrapib (AMG-899) is an inhibitor of cholesteryl ester transfer protein.

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Dalcetrapib

T6048211513-37-0

Dalcetrapib (RO4607381), a rhCETP inhibitor (IC50=0.2 μM), increases the plasma HDL cholesterol.

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Evacetrapib

T62621186486-62-3

Evacetrapib (LY2484595) (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.

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Torcetrapib

T2499262352-17-0

Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor designed to reduce the heterotypic transfer of cholesteryl ester from HDL to LDL and or VLDL. It failed in phase III trials due to an excess of deaths.

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Anacetrapib

T1928875446-37-0

Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and or VLDL thereby, producing an increase in serum HDL-cholesterol levels and a decrease in serum LDL-cholesterol levels.

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20-HC-Me-Pyrrolidine

T62380

20-HC-Me-Pyrrolidine is a potent Aster protein inhibitor with IC50=0.06~0.71 μm for Aster-A, Aster-B, and Aster-C that blocks the ability of Aster proteins to bind and transfer cholesterol, including inhibiting the movement of LDL cholesterol to the endoplasmic reticulum.

$201

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Erabulenol A

TN1026320887-73-4

Erabulenol A is a cholesterol ester transfer protein (CETP) inhibitor, extracted from Penicillumsp.

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10-14 weeks

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Implitapide

T15570177469-96-4

Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

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3-6 months

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TAP311

T13079

TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).

$1,970

10-14 weeks

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CP-532623

T15004261947-38-0

CP-532623, a close structural analog of Torcetrapib, is a CETP inhibitor with highly lipophilic properties. It elevates high-density lipoprotein cholesterol.

$987

6-8 weeks

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CP 524515

T204330262352-13-6

CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.

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10-14 weeks

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