product7/A-77-01.html

A 77-01 is a potent inhibitor of the TGF-(beta) type I receptor superfamily activin-like kinase ALK5, with an IC50 of 25 nM.

HG-7-86-01 (Compound 26), a type II tyrosine kinase inhibitor, exhibits anti-proliferative activity [1].

HG-7-85-01 is a type II ATP competitive inhibitor targeting wild-type and gatekeeper mutations of Bcr-Abl, PDGFRα, Kit, and Src kinases. It effectively inhibits T315I mutant Bcr-Abl kinase, as well as KDR and RET kinases with IC50 values of 3 nM, 20 nM, and 30 nM, respectively. HG-7-85-01 exhibits weak or no inhibition towards other kinases (IC50 >2 μM). Additionally, this compound inhibits cell proliferation by inducing apoptosis and impeding cell-cycle progression.

Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the formation of SNIPER [1].

HG-7-85-01-NH2, as the ligand for SNIPER(ABL)-033, effectively induces the reduction of BCR-ABL protein. This is achieved through SNIPER(ABL)-033, which connects HG-7-85-01 (an ABL inhibitor) to an LCL161 derivative (an IAP ligand) using a linker, demonstrating a DC50 value of 0.3 μM [1].