Ibuprofen
ID:T1394Hot Degree:
Size Price(USD) Stock Qty Select
2mg 20.00 In Stock
10mg 70.00 In Stock
50mg 114.00 In Stock
200mg 198.00 In Stock
10mM * 1mL (in DMSO) 37.00 In Stock

Quality management and product safety instructions
Related compound libraries
This product contains In the following compound libraries:
Product Information

HEREBY WE DECLARE TAHT ALL DATA ARE DEREIVED FROM PUBLIC RESOURCES, TARGETMOL IS NOT RESPONSIBLE FOR THEIR EFFECTIVENESS.

Biological Activity Figure

Pathway
Biological Activity:

Product Description

Ibuprofen (Motrin) is an anti-inflammatory inhibitor targeting COX-1 and COX-2, of which is used for pain relief, fever reduction and for reducing swelling.

Target

COX-2 COX-1 View more

IC50 Value

370μM 13μM

Diseases and Conditions

Nervous system
In vitro
In vivo
Chemical Information:

Molecular Weight

206.28

Storage

3years    -20 ℃    powder

2years    -80 ℃    In solvent

Formula

C13H18O2

CAS:

15687-27-1

Remark

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Solubility

In vitro

Ethanol

41 mg/mL (198.75 mM)

DMSO

41 mg/mL (198.75 mM)

Water

In vivo

1% DMSO+30% polyethylene glycol+1% Tween 80

20 mg/mL

* <1 mg/ml refers to the product slightly soluble or insoluble
Preparing Stock Solutions
Concentration Volume(DMSO) Mass
1mg 5mg 10mg
1mM 4.8478mL 24.2389mL 48.4778mL
5mM 0.9696mL 4.8478mL 24.2389mL
10mM 0.0485mL 2.4239mL 4.8478mL
50mM 0.0097mL 0.4848mL 2.4239mL
Reference
Clinical Data( Data from the:http:// clinicaltrials.gov)
Conversion of different model animals based on BSA(Value based on data from FDA Draft Guidelines)
Animal A (mg/kg)=Animal B(mg/kg)multiplied by

AnimalBm coefficient

 

AnimalAm coefficient

 

For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg

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Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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