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Neuronal Signaling Compound Library

Catalog No. L2600
  Library Compound List   Excel SDF

Communication between and within neurons is critical for all functions of the nervous system, from development to aging, through health and disease. The last decade has seen huge advances in our knowledge of the molecular, cellular and systematic signaling pathways within the nervous system. There have been significant breakthroughs in studies on the signaling pathways that underlie neurogenesis, addiction and autism spectrum disorders, as well as the pathophysiology and treatment of mood disorders. G protein-coupled receptors(GPCRs), including 5-HT receptors, histamine receptors, opioid receptors, are the largest family of signaling proteins to neuronal signaling. Changes in the GPCRs functioning can cause diseases many Neurological Disorders; Notch signaling is essential for proliferation, survival, self-renew, and differentiation of neural stem cells (NSCs). Notch signaling in neurons, glia and NSCs may be involved in pathological changes that occur in disorders such as stroke, Alzheimer’s disease and CNS tumors. Therefore, the potential of agents that target notch signaling could be used as therapeutic interventions for several different CNS disorders.

The Neuronal Signaling Compound Library by TargetMol, containing 2011 compounds targeting CNS signaling, can be used for high throughput screening and high content screening for new drugs in neurological disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 2011 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Targets include 5-HT receptor, AChR, Histamine receptor, dopamine receptor, Opioid receptor, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2600)

Library Composition

AChR (252)
5-HT Receptor (232)
COX (184)
Adrenergic Receptor (181)
Dopamine Receptor (152)
Histamine Receptor (103)
GABA Receptor (92)
GluR (78)
Opioid Receptor (67)
MAO (45)
NMDAR (45)
Beta Amyloid (33)
Adenosine Receptor (31)
P2 Receptor (30)
Prostaglandin Receptor (30)
Norepinephrine (25)
Gamma-secretase (24)
CaMK (24)
Potassium Channel (21)
Neurokinin receptor (21)
Cannabinoid Receptor (21)
NF-κB (21)
Hedgehog/Smoothened (20)
Calcium Channel (19)
S1P Receptor (18)
P-gp (17)
FAAH (17)
P450 (16)
OX Receptor (15)
Sigma receptor (15)
PDE (15)
Protease-activated Receptor (14)
Neuropeptide Y Receptor (14)
Lipoxygenase (13)
BACE (12)
Sodium Channel (12)
Melanocortin Receptor (11)
NOS (11)
TNF (10)
Endogenous Metabolite (10)
Endothelin Receptor (9)
GPCR19 (9)
PPAR (8)
LPA Receptor (8)
GPR (8)
GHSR (7)
ERK (7)
Serotonin Transporter (7)
Antioxidant (7)
Phospholipase (6)
Glucagon Receptor (6)
Estrogen/progestogen Receptor (6)
cAMP (6)
HIV Protease (6)
Antifection (6)
iGluR (6)
Parasite (6)
Vasopressin Receptor (6)
Autophagy (6)
PKA (6)
cholecystokinin (5)
IL Receptor (5)
Chloride channel (5)
MT Receptor (5)
ATPase (5)
Tyrosinase (5)
PKC (5)
TRP/TRPV Channel (5)
DNA/RNA Synthesis (5)
Caspase (5)
HDAC (5)
MPO (4)
Guanylate cyclase (4)
ROS (4)
Apoptosis (4)
EGFR (4)
MRP (4)
PI3K (4)
NADPH (4)
BCL (4)
Microtubule Associated (4)
VEGFR (4)
GRK (4)
Transferase (4)
MAPK (3)
Glucocorticoid Receptor (3)
Monoamine Oxidase (3)
Histone Demethylase (3)
Dehydrogenase (3)
PAFR (3)
STAT (3)
Casein Kinase (3)
GlyT (3)
CaSR (3)
GNRH Receptor (3)
Syk (3)
CDK (3)
Carbonic Anhydrase (3)
p38 MAPK (3)
MMP (3)
PARP (3)
Akt (3)
Ras (3)
ABC (3)
Antibacterial (3)
IAP (3)
IκB/IKK (3)
DNA Alkylation (2)
EBI2/GPR183 (2)
Cysteine Protease (2)
FAK (2)
mTOR (2)
Epigenetic Reader Domain (2)
GSK-3 (2)
Monoamine Transporter (2)
Melatonin Receptor (2)
FXR (2)
ROCK (2)
GTPase (2)
CRFR (2)
TGF-beta/Smad (2)
NOD (2)
Lipase (2)
Topoisomerase (2)
JNK (2)
transporter (2)
TSH Receptor (2)
UGT (2)
AChE (2)
LDL (2)
Integrin (2)
Immunology & Inflammation related (2)
Adiponectin receptor (2)
advanced glycation end products (2)
Amino Acids and Derivatives (2)
Androgen Receptor (2)
AMPK (2)
Antifungal (2)
NO Synthase (2)
Thrombin (2)
Bradykinin Receptor (2)
Oxytocin Receptor (2)
IGF-1R (1)
HIF (1)
MEK (1)
GPX (1)
Histone Methyltransferase (1)
HCV Protease (1)
Liver X Receptor (1)
Leukotriene Receptor (1)
HMG-CoA Reductase (1)
GST (1)
lysosomal autophagy (1)
Hydroxylase (1)
MAGL (1)
HER (1)
Melanin-concentrating Hormone Receptor (MCHR) (1)
Aurora Kinase (1)
Glucokinase (1)
Retinoid Receptor (1)
Vitamin (1)
Transaminase (1)
Src (1)
Somatostatin (1)
Sirtuin (1)
ROR (1)
Rho (1)
Raf (1)
Adenylyl cyclase (1)
Pim (1)
p53 (1)
NMU2R (1)
Neurotensin Receptor (1)
Na-K-Cl cotransporter (1)
N-Acetylglucosaminyltransferase (1)
Monocarboxylate transporter (1)
Acyltransferase (1)
Anion Exchanger (1)
GluCls (1)
cell cycle arrest (1)
Gap Junction Protein (1)
Free radical scavengers (1)
Ferroptosis (1)
DYRK (1)
DNA Methyltransferase (1)
c-RET (1)
CGRP Receptor (1)
CCR (1)
Annexin A (1)
CAT (1)
Bombesin Receptor (1)
Beta-Secretase (1)
BCRP (1)
Bcr-Abl (1)
Apelin receptor (1)
Antiviral (1)
Antifolate (1)
MicroRNA (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE