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(R)-SCH 42495

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Catalog No. T12641Cas No. 156792-25-5

(R)-SCH 42495, the less active enantiomer of SCH 42495, is an orally active inhibitor of neutral metalloendopeptidase (NEP) with antihypertensive effects.

(R)-SCH 42495
Other Forms of (R)-SCH 42495:

(R)-SCH 42495

😃Good
Catalog No. T12641Cas No. 156792-25-5
(R)-SCH 42495, the less active enantiomer of SCH 42495, is an orally active inhibitor of neutral metalloendopeptidase (NEP) with antihypertensive effects.
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Product Introduction

Bioactivity
Description
(R)-SCH 42495, the less active enantiomer of SCH 42495, is an orally active inhibitor of neutral metalloendopeptidase (NEP) with antihypertensive effects.
In vitro
NEP is a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro[1].
Chemical Properties
Molecular Weight411.58
FormulaC20H29NO4S2
Cas No.156792-25-5
Relative Density.1.158 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

SCH 42495(R) SCH 42495(R)SCH 42495SCH-42495SCH42495
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