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α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1] |
Targets&IC50 | hCA:7.0 nM (Ki), hCA IX:64.1 nM (Ki), hCA XII:19.9 nM (Ki) |
In vitro | α-Glucosidase-IN-63 inhibits human carbonic anhydrase (hCA) with K i values of 7.0 nM for hCA II, 19.9 nM for hCA XII, and 64.1 nM for hCA IX [1]. |
In vivo | α-Glucosidase-IN-63 (p.o.) exhibits a notable hypoglycemic effect in streptozotocin-induced diabetic mice, significantly improving glucose tolerance and outperforming the standard drug Acarbose [1]. |
Molecular Weight | 377.41 |
Formula | C16H12FN3O3S2 |
Cas No. | 2375866-82-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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