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16-phenoxy tetranor Prostaglandin F2α methyl ester

Catalog No. T37937 CAS 51638-90-5

Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.

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16-phenoxy tetranor Prostaglandin F2α methyl ester, CAS 51638-90-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	404.503
Formula	C23H32O6
CAS No.	51638-90-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL

Ethanol: 100 mg/mL

PBS (pH 7.2): 0.5 mg/mL

DMF: 100 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

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Keywords

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