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17-phenyl trinor Prostaglandin F2α isopropyl ester

Catalog No. T37943 CAS 130209-76-6

Synonyms: 17-phenyl trinor Prostaglandin F2α isopropyl ester

17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost. At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.

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17-phenyl trinor Prostaglandin F2α isopropyl ester Chemical Structure

17-phenyl trinor Prostaglandin F2α isopropyl ester, CAS 130209-76-6

Pack Size	Availability	Price/USD
1 mg	4-5 weeks	$ 183.00
5 mg	4-5 weeks	$ 793.00
10 mg	4-5 weeks	$ 1,430.00

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Biological Description

Chemical Properties

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Description

Synonyms	17-phenyl trinor Prostaglandin F2α isopropyl ester
Molecular Weight	430.58
Formula	C26H38O5
CAS No.	130209-76-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 30 mg/mL

DMSO: 30 mg/mL

Ethanol: 50 mg/mL

Ethanol:PBS (pH 7.2) (1:1): 1 mg/mL

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Keywords

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