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8-Chloro-cAMP sodium
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Catalog No. T88665Cas No. 124705-03-9
8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.
8-Chloro-cAMP sodium
😃Good
Catalog No. T88665Cas No. 124705-03-9
8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity. |
| In vitro | 8-Chloro-cAMP sodium significantly reduces the proliferation of vascular smooth muscle cells (VSMC) in vitro, diminishes the expression of protein kinase A (PKA) RIα subunit, and promotes the expression of PKA RIIβ subunit. |
| In vivo | In a study involving rats with balloon injuries, 8-Chloro-cAMP (12 mg/kg) sodium was shown to decrease the neointimal area and neointima/media ratio in a dose-dependent fashion following the injury. Furthermore, 8-Chloro-cAMP was effective in reducing the proliferative activity of VSMCs in vivo. |
| Molecular Weight | 385.63 |
| Formula | C10H10ClN5NaO6P |
| Cas No. | 124705-03-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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