Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells cultured in CSF-1 (IC50 = 38 nM) or IL-34 (IC50 = 40 nM) and inhibited the differentiation and survival of primary human osteoclasts mediated by CSF-1 (IC50 = 15nM). AC708 showed significant specificity in kinase selectivity tests against CSF1R and the closely related PDGFR family of receptors PDGFRα and β, FLT3 and KIT.
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Description | AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells cultured in CSF-1 (IC50 = 38 nM) or IL-34 (IC50 = 40 nM) and inhibited the differentiation and survival of primary human osteoclasts mediated by CSF-1 (IC50 = 15nM). AC708 showed significant specificity in kinase selectivity tests against CSF1R and the closely related PDGFR family of receptors PDGFRα and β, FLT3 and KIT. |
Synonyms | AC 708, AC-708 |
Molecular Weight | N/A |
CAS No. | T29542 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AC708 T29542 AC 708 AC-708 inhibitor inhibit