BAA473

BAA473, a bile acid analog, is a potent activator of the pyrin inflammasome, inducing secretion of interleukin-18 (IL-18) through inflammasome activation in both myeloid and intestinal epithelial cells [1].

Catalog No. T10447

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BAA473

Catalog No. T10447

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Pack Size	Price	Availability
25 mg	$1,520	10-14 weeks
50 mg	$1,980	10-14 weeks
100 mg	$2,500	10-14 weeks

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Product Introduction

Bioactivity

Description	BAA473, a bile acid analog, is a potent activator of the pyrin inflammasome, inducing secretion of interleukin-18 (IL-18) through inflammasome activation in both myeloid and intestinal epithelial cells [1].
In vitro	BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) induces LPS-primed cell death in THP-1-Cas9 cells. [1]. Cell Viability Assay [1] Cell Line: THP-1-Cas9 cells; Concentration: 0 μM, 0.1 μM, 0.4 μM, 1.2 μM, 3.7 μM, 11 μM, 33 μM; Incubation Time: 24 hours; Result: Induced cell death.

Chemical Properties

Molecular Weight	574.87
Formula	C₃₆H₆₂O₅
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

BAA473BAA-473BAA 473